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580563 TCPOBOP - CAS 76150-91-9 - Calbiochem

The most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents.

TCPOBOP - CAS 76150-91-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene

Primary Target: Cytochrome P450 (CYP)-inducing agents
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
76150-91-9C₁₆H₈Cl₄N₂O₂

Products

Catalogue NumberPackaging Qty/Pack
580563-25MG Plastic ampoule 25 mg
Description
OverviewThe most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents. Acts as a tumor promoter of murine hepatocarcinogenesis; activates orphan nuclear receptors mCAR (mouse Constitutive Androstane Receptor) and hPXR (human Pregnane X Receptor), but has little or no activity on hCAR and mPXR. Also suppresses the multidrug resistance gene expression in the mouse liver.
Catalogue Number580563
Brand Family Calbiochem®
Synonyms1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene
References
ReferencesLedda-Columbano, G.M., et al. 2000. Am. J. Pathol. 156, 91.
Moore, L.B., et al. 2000. J. Biol. Chem. 275, 15122.
Tzameli, I., et al. 2000. Mol. Cell. Biol. 20, 2951.
Forman, B.M., et al. 1998. Nature 395, 612.
Honkakoski, P., et al. 1998. Mol. Pharmacol. 53, 597.
Russell, A.L., et al. 1994. Int. J. Cancer 58, 550.
Smith, G., et al. 1993. Biochem. J. 289, 807.
Dargani, T.A., et al. 1990. Carcinogenesis 11, 1153.
Poland, A., et al. 1980. Mol. Pharmacol. 18, 571.
Product Information
CAS number76150-91-9
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₆H₈Cl₄N₂O₂
Chemical formulaC₁₆H₈Cl₄N₂O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCytochrome P450 (CYP)-inducing agents
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUT7145000
Safety Information
R PhraseR: 40

Limited evidence of a carcinogenic effect.
S PhraseS: 22-36

Do not breathe dust.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
580563-25MG 04055977265576

Documentation

TCPOBOP - CAS 76150-91-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

TCPOBOP - CAS 76150-91-9 - Calbiochem Certificates of Analysis

TitleLot Number
580563

References

Reference overview
Ledda-Columbano, G.M., et al. 2000. Am. J. Pathol. 156, 91.
Moore, L.B., et al. 2000. J. Biol. Chem. 275, 15122.
Tzameli, I., et al. 2000. Mol. Cell. Biol. 20, 2951.
Forman, B.M., et al. 1998. Nature 395, 612.
Honkakoski, P., et al. 1998. Mol. Pharmacol. 53, 597.
Russell, A.L., et al. 1994. Int. J. Cancer 58, 550.
Smith, G., et al. 1993. Biochem. J. 289, 807.
Dargani, T.A., et al. 1990. Carcinogenesis 11, 1153.
Poland, A., et al. 1980. Mol. Pharmacol. 18, 571.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-September-2008 RFH
Synonyms1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene
DescriptionA highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number76150-91-9
RTECSUT7145000
Chemical formulaC₁₆H₈Cl₄N₂O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesLedda-Columbano, G.M., et al. 2000. Am. J. Pathol. 156, 91.
Moore, L.B., et al. 2000. J. Biol. Chem. 275, 15122.
Tzameli, I., et al. 2000. Mol. Cell. Biol. 20, 2951.
Forman, B.M., et al. 1998. Nature 395, 612.
Honkakoski, P., et al. 1998. Mol. Pharmacol. 53, 597.
Russell, A.L., et al. 1994. Int. J. Cancer 58, 550.
Smith, G., et al. 1993. Biochem. J. 289, 807.
Dargani, T.A., et al. 1990. Carcinogenesis 11, 1153.
Poland, A., et al. 1980. Mol. Pharmacol. 18, 571.