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538001 T-00127-HEV1 - CAS 900874-91-1 - Calbiochem

T-00127-HEV1 - CAS 900874-91-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(3,4-Dimethoxyphenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine, PI4KIIIβ Inhibitor II

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
900874-91-1C₂₂H₂₉N₅O₃
Description
Overview

This product has been discontinued.



A cell-permeable pyrazolopyrimidinamine derived enviroxime-like compound that displays anti-poliovirus activity with broad specificity for enteroviruses (EC50 = 0.77, 3.38, 2.5, 1.03 & >44 µM for PV, CVB3, HRVM, HCV 1b & HCV 2a, respectively). Dose-dependently inhibits viral RNA replication. Acts as a potent, selective, ATP-competitive and reversible inhibitor of PI4KIIIβ (IC50 = 150 nM) with poor affinity towards PI4KIIIα & PI4KIIα (IC50 = ~75 & ≥100 µM). Shown to cause PI4KIIIβ accumulation and reduce PI4P at the Golgi apparatus. Exhibits low cytotoxicity (CC50 > 50 µM in HeLa cells) and attractive PK profile in mice. PI4KIIIβ Inhibitor I, BF738735 (Cat. No. 533657) is also available.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number538001
Brand Family Calbiochem®
Synonyms3-(3,4-Dimethoxyphenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine, PI4KIIIβ Inhibitor II
DescriptionT-00127-HEV1
References
ReferencesMejdrova, I., et al. 2015. J. Med. Chem. 58, In press.
Spickler, C., et al. 2013. Antimicrob. Agents Chemother. 57, 3358.
Sasaki, J., et al. 2012. EMBO J. 31, 754.
Arita, M., et al. 2011. J. Virol. 85, 2364.
Product Information
CAS number900874-91-1
FormOff-whte solid
Hill FormulaC₂₂H₂₉N₅O₃
Chemical formulaC₂₂H₂₉N₅O₃
ReversibleY
Quality LevelMQ200
Applications
Biological Information
Primary TargetPI4KIIIβ
Primary Target IC<sub>50</sub>150 nM for PI4KIII&beta
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
538001 0

Documentation

T-00127-HEV1 - CAS 900874-91-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Mejdrova, I., et al. 2015. J. Med. Chem. 58, In press.
Spickler, C., et al. 2013. Antimicrob. Agents Chemother. 57, 3358.
Sasaki, J., et al. 2012. EMBO J. 31, 754.
Arita, M., et al. 2011. J. Virol. 85, 2364.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-August-2016 JSW
Synonyms3-(3,4-Dimethoxyphenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine, PI4KIIIβ Inhibitor II
DescriptionA cell-permeable pyrazolopyrimidinamine derived enviroxime-like compound that displays anti-poliovirus activity with broad specificity for enteroviruses (EC50 = 0.77, 3.38, 2.5, 1.03 & >44 µM for PV, CVB3, HRVM, HCV 1b & HCV 2a, respectively). Dose-dependently inhibits viral RNA replication. Acts as a potent, selective, ATP-competitive and reversible inhibitor of PI4KIIIβ (IC50 = 150 nM) with poor affinity towards PI4KIIIα & PI4KIIα (IC50 = ~75 & ≥100 µM). Shown to cause PI4KIIIβ accumulation and reduce PI4P at the Golgi apparatus. Exhibits low cytotoxicity (CC50 > 50 µM in HeLa cells) and attractive PK profile in mice. PI4KIIIβ Inhibitor I, BF738735 (Cat. No. 533657) is also available.
FormOff-whte solid
Intert gas (Yes/No) Packaged under inert gas
CAS number900874-91-1
Chemical formulaC₂₂H₂₉N₅O₃
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesMejdrova, I., et al. 2015. J. Med. Chem. 58, In press.
Spickler, C., et al. 2013. Antimicrob. Agents Chemother. 57, 3358.
Sasaki, J., et al. 2012. EMBO J. 31, 754.
Arita, M., et al. 2011. J. Virol. 85, 2364.