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567060 Siomycin A, Streptomyces sioyaensis - Calbiochem

Siomycin A, Streptomyces sioyaensis, CAS 12656-09-6, is a cell-permeable macrocyclic antibiotic that inhibits bacterial protein synthesis (IC50 = 250 nM) by interfering with rRNA binding.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC 285116, FOXM1 Inhibitor II

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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₇₁H₈₁N₁₉O₁₈S₅
Description
OverviewA cell-permeable thiostrepton (Cat. No. 598226) family macrocyclic peptide antibiotic that inhibits bacterial protein synthesis (IC50 = 250 nM) by interfering with rRNA binding. Shown to inhibit mammalian FoxM1 (forkhead box M1) function in C3 cells by negatively regulating its transcriptional activity (IC50 ≤5 µM), phosphorylation, as well as mRNA (>60% reduction at 10 µM) and protein (>90% reduction at 20 µM) abundance. Selectively induces apoptosis in SV40-transformed MRC-5 human fetal lung fibroblasts, but not the non-transformed wild-type cells.
Catalogue Number567060
Brand Family Calbiochem®
SynonymsNSC 285116, FOXM1 Inhibitor II
References
ReferencesPriller, M., et al. 2011. Clin. Cancer Res. 17, 6791.
Radhakrishnan, S.K., et al. 2006. Cancer Res. 66, 9731.
Erdal, H., et al. Proc. Natl. Acad. Sci. USA 102, 192.
Lentzen, G., et al. 2003. Chem. Biol. 10, 769.
Product Information
FormWhite solid
Hill FormulaC₇₁H₈₁N₁₉O₁₈S₅
Chemical formulaC₇₁H₈₁N₁₉O₁₈S₅
Quality LevelMQ100
Applications
ApplicationSiomycin A, Streptomyces sioyaensis, CAS 12656-09-6, is a cell-permeable macrocyclic antibiotic that inhibits bacterial protein synthesis (IC50 = 250 nM) by interfering with rRNA binding.
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-24/25-36/37-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing and gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
567060 0

Documentation

Siomycin A, Streptomyces sioyaensis - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Siomycin A, Streptomyces sioyaensis - Calbiochem Certificates of Analysis

TitleLot Number
567060

References

Reference overview
Priller, M., et al. 2011. Clin. Cancer Res. 17, 6791.
Radhakrishnan, S.K., et al. 2006. Cancer Res. 66, 9731.
Erdal, H., et al. Proc. Natl. Acad. Sci. USA 102, 192.
Lentzen, G., et al. 2003. Chem. Biol. 10, 769.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-November-2011 JSW
SynonymsNSC 285116, FOXM1 Inhibitor II
DescriptionA cell-permeable thiostrepton (Cat. No. 598226) family macrocyclic peptide antibiotic that inhibits bacterial protein synthesis (IC50 = 250 nM) by interfering with rRNA binding. Shown to inhibit mammalian FoxM1 (forkhead box M1) function in C3 cells by negatively regulating its transcriptional activity (IC50 ≤5 µM), phosphorylation, as well as mRNA (>60% reduction at 10 µM) and protein (>90% reduction at 20 µM) abundance. Selectively induces apoptosis in SV40-transformed MRC-5 human fetal lung fibroblasts, but not the non-transformed wild-type cells.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₇₁H₈₁N₁₉O₁₈S₅
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesPriller, M., et al. 2011. Clin. Cancer Res. 17, 6791.
Radhakrishnan, S.K., et al. 2006. Cancer Res. 66, 9731.
Erdal, H., et al. Proc. Natl. Acad. Sci. USA 102, 192.
Lentzen, G., et al. 2003. Chem. Biol. 10, 769.