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573131 STAT3 Inhibitor XIV, LLL12 - Calbiochem

The STAT3 Inhibitor XIV, LLL12 controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

STAT3 Inhibitor XIV, LLL12 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide

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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₄H₉NO₅S
Description
OverviewA cell-permeable hydroxyanthraquinone compound that binds directly to the phosphoryl Tyr705 binding site of the STAT3 monomer and acts as selective and reversible inhibitor of STAT3 signaling. Shown to block STAT3 phosphorylation and its subsequent nuclear localization and DNA binding, but has no effect on IL-4, interferon-α and interferon-γ-induced STAT1, 2, 4, 6 and pJAK2, PI3-Kinase, or ERK signaling. Does not affect the activity of over 21 other closely related protein kinases (IC50 > 50 µM). Also shown to induce apoptosis in U266 and ARH-77 multiple myeloma cell lines (IC50 = 490 nM and 1.96 µM, respectively), and suppress hepatocellular carcinoma tumor growth in xenograft mouse model (5 mg/kg, i.v).
Catalogue Number573131
Brand Family Calbiochem®
Synonyms5-Hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide
References
ReferencesLin, L., et al. 2011. Cancer Res. 71, 7226.
Lin, L., et al. 2011. Int. J. Cancer in press.
Ball, S., et al. PLoS One 6, e18820.
Liu, Y., et al. 2010. J. Biol. Chem. 285, 27429.
Lin, L., et al. 2010. Neoplasia 12, 39.
Product Information
FormOrange powder
Hill FormulaC₁₄H₉NO₅S
Chemical formulaC₁₄H₉NO₅S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
573131 0

Documentation

STAT3 Inhibitor XIV, LLL12 - Calbiochem Certificates of Analysis

TitleLot Number
573131

References

Reference overview
Lin, L., et al. 2011. Cancer Res. 71, 7226.
Lin, L., et al. 2011. Int. J. Cancer in press.
Ball, S., et al. PLoS One 6, e18820.
Liu, Y., et al. 2010. J. Biol. Chem. 285, 27429.
Lin, L., et al. 2010. Neoplasia 12, 39.

Technical Info

Title
JAK/STAT Signaling Research Focus
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-July-2012 JSW
Synonyms5-Hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide
DescriptionA cell-permeable hydroxyanthraquinone compound that binds directly to the phosphoryl Tyr705 binding site of the STAT3 monomer and acts as selective and reversible inhibitor of STAT3 signaling. Shown to block STAT3 phosphorylation and its subsequent nuclear localization and DNA binding, but has no effect on IL-4, interferon-α and interferon-γ-induced STAT1, 2, 4, 6 and pJAK2, PI3-Kinase, or ERK signaling. Does not affect the activity of over 21 other closely related protein kinases (IC50 > 50 µM). Also shown to induce apoptosis in U266 and ARH-77 multiple myeloma cell lines (IC50 = 490 nM and 1.96 µM, respectively), and suppress hepatocellular carcinoma tumor growth in xenograft mouse model (5 mg/kg, i.v).
FormOrange powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₄H₉NO₅S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLin, L., et al. 2011. Cancer Res. 71, 7226.
Lin, L., et al. 2011. Int. J. Cancer in press.
Ball, S., et al. PLoS One 6, e18820.
Liu, Y., et al. 2010. J. Biol. Chem. 285, 27429.
Lin, L., et al. 2010. Neoplasia 12, 39.