500519 Sigma-AldrichSKP2 E3 Ligase Inhibitor I, C1 - CAS 432001-69-9 - Calbiochem
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Primary Target:
disrupts p27-Skp2 interaction
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: p21/Cip1/Waf1 Activator I; p27/Kip1 Activator I, S-phase Kinase-associated Protein 2 Inhibitor I; SCFSKP2 Inhibitor I, CRL1SKP2 Inhibitor I, (Z)-2-(4-Bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 432001-69-9 | C₁₈H₁₃BrN₂O₄S₂ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 5.00519.0001 | Glass bottle | 25 mg |
| Description | |
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| Overview | A cell-permeable rhodanine compound that upregulates cellular p21Cip1/Waf1 and p27Kip1 protein levels (10 µM for 16 h in 501 Mel cultures) by preventing Skp2-Cks1-mediated substrate recruitment without affecting the F-box E3 ubiquitin ligase Skp2 interaction with Cks1 or the SCF (Skp1-cullin1-F-box) complex. Shown to inhibit the proliferation of human breast cancer MCF-7 and melanoma 501 Mel cells (IC50 = 8 and 30 µM, respectively; 16 h incubation). Unlike SMIP004 (Cat. No. 500517), C1 does not affect cellular Cyclin E/CDK2 kinase activity or Skp2 level. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
| Catalogue Number | 500519 |
| Brand Family | Calbiochem® |
| Synonyms | p21/Cip1/Waf1 Activator I; p27/Kip1 Activator I, S-phase Kinase-associated Protein 2 Inhibitor I; SCFSKP2 Inhibitor I, CRL1SKP2 Inhibitor I, (Z)-2-(4-Bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid |
| References | |
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| References | Rico-Bautista, E., and Wolf, D.A. 2012. Chem. Biol. 19, 1497. Wu, L., et al. 2012. Chem. Biol. 19, 1515. |
| Product Information | |
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| CAS number | 432001-69-9 |
| Form | Orange brown powder |
| Hill Formula | C₁₈H₁₃BrN₂O₄S₂ |
| Chemical formula | C₁₈H₁₃BrN₂O₄S₂ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | disrupts p27-Skp2 interaction |
| Purity | ≥99% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 5.00519.0001 | 04055977245752 |
Documentation
SKP2 E3 Ligase Inhibitor I, C1 - CAS 432001-69-9 - Calbiochem SDS
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References
| Reference overview |
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| Rico-Bautista, E., and Wolf, D.A. 2012. Chem. Biol. 19, 1497. Wu, L., et al. 2012. Chem. Biol. 19, 1515. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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