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509708 SKF-97541 - CAS 127729-35-5 - Calbiochem

A highly potent agonist of GABAB receptor. Shown to be about 10-times more potent than baclofen.

SKF-97541 - CAS 127729-35-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GABAB Receptor Agonist, SKF-97541, SKF 97541, CGP 35024, 3-APMPA

Primary Target: GABAB
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
127729-35-5C₄H₁₂NO₂P

Products

Catalogue NumberPackaging Qty/Pack
5.09708.0001 Glass bottle 10 mg
Description
OverviewA highly potent agonist of GABAB receptor. Depresses excitatory postsynaptic potentials mediated by glutamate in the striatum, and hyperpolarized neurones in the substantia nigra (IC50 = 92 nM). Shown to be about 10-times more potent than baclofen (Cat. No. 505873). Induces vasodepression in pulmonary vascular bed that is modulated by an ATP-sensitive K+ channel. Induces gastric acid secretion in a dose-dependent manner (0.01 - 3 mg/kg, i.v.) in mice.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number509708
Brand Family Calbiochem®
SynonymsGABAB Receptor Agonist, SKF-97541, SKF 97541, CGP 35024, 3-APMPA
References
ReferencesKaye, A.D., et al. 2004. Anesth. Analg. 99, 758.
Piqueras, L., and Martinez, V. 2004. Br. J. Pharmacol. 142, 1038.
Seabrook, G.R., et al. 1990. Br. J. Pharmacol. 101, 949.
Product Information
CAS number127729-35-5
FormWhite solid
Hill FormulaC₄H₁₂NO₂P
Chemical formulaC₄H₁₂NO₂P
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGABAB
Purity≥98% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.09708.0001 04055977241082

Documentation

SKF-97541 - CAS 127729-35-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Kaye, A.D., et al. 2004. Anesth. Analg. 99, 758.
Piqueras, L., and Martinez, V. 2004. Br. J. Pharmacol. 142, 1038.
Seabrook, G.R., et al. 1990. Br. J. Pharmacol. 101, 949.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-February-2014 JSW
SynonymsGABAB Receptor Agonist, SKF-97541, SKF 97541, CGP 35024, 3-APMPA
DescriptionA highly potent agonist of GABAB receptor. Depresses excitatory postsynaptic potentials mediated by glutamate in the striatum, and hyperpolarized neurones in the substantia nigra (IC50 = 92 nM). Shown to be about 10-times more potent than baclofen (Cat. No. 505873). Induces vasodepression in pulmonary vascular bed that is modulated by an ATP-sensitive K+ channel. Induces gastric acid secretion in a dose-dependent manner (0.01 - 3 mg/kg, i.v.) in mice.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number127729-35-5
Chemical formulaC₄H₁₂NO₂P
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityH₂O (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKaye, A.D., et al. 2004. Anesth. Analg. 99, 758.
Piqueras, L., and Martinez, V. 2004. Br. J. Pharmacol. 142, 1038.
Seabrook, G.R., et al. 1990. Br. J. Pharmacol. 101, 949.