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565851 SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem

SHP1/2 PTPase Inhibitor, NSC-87877, CAS 56932-43-5, is a cell-permeable, potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 tyrosine phosphatases (IC50 = 355 nM & 318 nM, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I

Primary Target: SHP1/2 PTPase
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
56932-43-5C₁₉H₁₁N₃Na₂O₇S₂

Products

Catalogue NumberPackaging Qty/Pack
565851-50MG Glass bottle 50 mg
Description
OverviewA cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC50 = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC50 = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.
Catalogue Number565851
Brand Family Calbiochem®
Synonyms8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I
References
ReferencesChen, L., et al. 2006. Mol. Pharmacol. 70, 562.
Product Information
CAS number56932-43-5
ATP CompetitiveN
FormRedish brown solid
Hill FormulaC₁₉H₁₁N₃Na₂O₇S₂
Chemical formulaC₁₉H₁₁N₃Na₂O₇S₂
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationSHP1/2 PTPase Inhibitor, NSC-87877, CAS 56932-43-5, is a cell-permeable, potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 tyrosine phosphatases (IC50 = 355 nM & 318 nM, respectively).
Biological Information
Primary TargetSHP1/2 PTPase
Primary Target IC<sub>50</sub>355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
565851-50MG 04055977191271

Documentation

SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem Certificates of Analysis

TitleLot Number
565851

References

Reference overview
Chen, L., et al. 2006. Mol. Pharmacol. 70, 562.

Brochure

Title
An Introduction to Inhibitors and Their Biological Applications - 1st Edition
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-September-2008 RFH
Synonyms8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I
DescriptionA cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC50 = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC50 = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.
FormRedish brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number56932-43-5
Chemical formulaC₁₉H₁₁N₃Na₂O₇S₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityH₂O (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesChen, L., et al. 2006. Mol. Pharmacol. 70, 562.