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565610 SC-560 - CAS 188817-13-2 - Calbiochem

A cell-permeable, highly potent and selective inhibitor of COX-1 (IC₅₀ = 9 nM).

SC-560 - CAS 188817-13-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole

Primary Target: COX-1
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
188817-13-2C₁₇H₁₂CIF₃N₂O
Description
OverviewA cell-permeable, highly potent and selective inhibitor of COX-1 (IC50 = 9 nM). Inhibits COX-2 only at higher concentrations (IC50 = 6.3 µM).
Catalogue Number565610
Brand Family Calbiochem®
Synonyms5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole
References
ReferencesOstrom, R.S., et al. 2001. Am. J. Physiol. Cell Physiol.281, C524.
Smith, C.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13313.
Product Information
CAS number188817-13-2
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₇H₁₂CIF₃N₂O
Chemical formulaC₁₇H₁₂CIF₃N₂O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCOX-1
Primary Target IC<sub>50</sub>9 nM against COX-1
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
565610 0

Documentation

SC-560 - CAS 188817-13-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

SC-560 - CAS 188817-13-2 - Calbiochem Certificates of Analysis

TitleLot Number
565610

References

Reference overview
Ostrom, R.S., et al. 2001. Am. J. Physiol. Cell Physiol.281, C524.
Smith, C.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13313.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2008 RFH
Synonyms5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole
DescriptionA cell-permeable, highly potent and selective inhibitor of cyclooxygenase-1 (COX-1; IC50 = 9 nM). Inhibits cyclooxygenase-2 (COX-2) only at higher concentrations (IC50 = 6.3 µM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number188817-13-2
Chemical formulaC₁₇H₁₂CIF₃N₂O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (200 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesOstrom, R.S., et al. 2001. Am. J. Physiol. Cell Physiol.281, C524.
Smith, C.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13313.