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531547 RyR1 Modulator, CCDI - Calbiochem

A cell-permeable compound that selectively and reversibly binds to the cytoplasmic domain of mammalian RyR1 and potentiates Ca2+-dependent binding of [3H]-ryanodine to RyR1(EC₅₀ = 6 µM).

RyR1 Modulator, CCDI - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ryanodine Receptor 1 Modulator

Primary Target: RyR1
531547
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₈H₂₅N₃O
Description
Overview

This product has been discontinued.



A cell-permeable pyrrolo[1,2-c]imidazolone derived compound that selectively and preferentially binds to the cytoplasmic domain of mammalian ryanodine receptor 1 (RyR1) in a reversible manner and potentiates Ca2+-dependent binding of [3H]-ryanodine to RyR1(EC50 = 6 µM). Increases the open probability (Po) of RyR1 without affecting RyR2, RyR3, or the IP3R. Does not alter RyR1 conductance or the Kd for 3H-ryanodine binding to RyR1 in any significant manner (~4 nM vs 4.2 nM with and without CCDI in the medium). Induces Ca2+ transients in C2C12 skeletal myotubes, but does not alter Ca2+ transients in rat ventricular myocytes.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Catalogue Number531547
Brand Family Calbiochem®
SynonymsRyanodine Receptor 1 Modulator
References
ReferencesTian, C., et al. 2014. Br. J. Pharmcol. 171, 4097.
Product Information
FormOff-white solid
Hill FormulaC₁₈H₂₅N₃O
Chemical formulaC₁₈H₂₅N₃O
Quality LevelMQ100
Applications
Biological Information
Primary TargetRyR1
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
531547 0

Documentation

RyR1 Modulator, CCDI - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Tian, C., et al. 2014. Br. J. Pharmcol. 171, 4097.

Brochure

Title
NPI Flyer- Epigenetics and Nuclear Function Feature
New Products - Antibodies, Small Molecule, Inhibitors

Technical Info

Title
White Paper: Further considerations of antibody validation and usage.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-October-2014 JSW
SynonymsRyanodine Receptor 1 Modulator
DescriptionA cell-permeable pyrrolo[1,2-c]imidazolone derived compound that selectively and preferentially binds to the cytoplasmic domain of mammalian ryanodine receptor 1 (RyR1) in a reversible manner and potentiates Ca2+-dependent binding of [3H]-ryanodine to RyR1(EC50 = 6 µM). Increases the open probability (Po) of RyR1 without affecting RyR2, RyR3, or the IP3R. Does not alter RyR1 conductance or the Kd for 3H-ryanodine binding to RyR1 in any significant manner (~4 nM vs 4.2 nM with and without CCDI in the medium). Induces Ca2+ transients in C2C12 skeletal myotubes, but does not alter Ca2+ transients in rat ventricular myocytes.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₈H₂₅N₃O
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTian, C., et al. 2014. Br. J. Pharmcol. 171, 4097.