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555551 Rho Kinase Inhibitor II - CAS 97627-27-5 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-Pyridyl)-Nʹ-(2,4,6-trichlorophenyl)urea

Primary Target: ROCK
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
97627-27-5C₁₂H₈Cl₃N₃O
Description
Overview

This product has been discontinued.



A pyridyl urea compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Rho-associated protein kinase (ROCK; IC50 = 0.2 µM). Displays little activity towards Erk, PKA, PKC, PDGFR, or c-Kit/SCFR (IC50 > 10 µM).
Catalogue Number555551
Brand Family Calbiochem®
SynonymsN-(4-Pyridyl)-Nʹ-(2,4,6-trichlorophenyl)urea
References
ReferencesTakami, A., et al. 2004. Bioorg. Med. Chem. 12, 2115.
Product Information
CAS number97627-27-5
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₂H₈Cl₃N₃O
Chemical formulaC₁₂H₈Cl₃N₃O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetROCK
Primary Target IC<sub>50</sub>0.2 µM
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
555551 0

Documentation

Rho Kinase Inhibitor II - CAS 97627-27-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Rho Kinase Inhibitor II - CAS 97627-27-5 - Calbiochem Certificates of Analysis

TitleLot Number
555551

References

Reference overview
Takami, A., et al. 2004. Bioorg. Med. Chem. 12, 2115.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
SynonymsN-(4-Pyridyl)-Nʹ-(2,4,6-trichlorophenyl)urea
DescriptionA potent, selective, and ATP-competitive inhibitor of Rho-associated protein kinase (ROCK; IC50 = 200 nM). Does not significantly inhibit the activities of Erk, PKA, PKC, PDGFR, or c-Kit/SCFR (IC50 > 10 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number97627-27-5
Chemical formulaC₁₂H₈Cl₃N₃O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTakami, A., et al. 2004. Bioorg. Med. Chem. 12, 2115.