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538925 Prostaglandin I₂, Sodium Salt - CAS 61849-14-7 - Calbiochem

Potent vasodilatory prostaglandin produced by the endothelium.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PGI₂, Prostacyclin

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
61849-14-7C₂₀H₃₁O₅ · Na
Description
Overview

This product has been discontinued.



Potent vasodilatory prostaglandin produced by the endothelium. Induces vasodilation, stimulates cAMP formation. Exhibits cytoprotective and fibrinolytic properties.
Catalogue Number538925
Brand Family Calbiochem®
SynonymsPGI₂, Prostacyclin
References
ReferencesVane, J.R. 1985. Adv. Prostaglandin Thromboxane Leukotriene Res. 15, 11.
Moncada, S., et al. 1979. Pharmacol. Rev. 30, 293.
Cho, M.J. and Allen, M.A. 1978. Prostaglandins 15, 943.
Tateson, J.E., et al. 1977. Prostaglandins 13, 389.
Product Information
CAS number61849-14-7
ATP CompetitiveN
FormCrystalline solid
Hill FormulaC₂₀H₃₁O₅ · Na
Chemical formulaC₂₀H₃₁O₅ · Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetInduces vasodilation
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-36

Do not breathe dust.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Harmful
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). This product is rapidly hydrolyzed in acidic solutions. The half-life at pH 7.48 is between 3.5 min and 10.5 min at 25°C. At pH 12 the half-life is ~6 days at 25°C. No loss of biological activity was observed at pH 9.37 for 48 h, when stored at 0°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
538925 0

Documentation

Prostaglandin I₂, Sodium Salt - CAS 61849-14-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Prostaglandin I₂, Sodium Salt - CAS 61849-14-7 - Calbiochem Certificates of Analysis

TitleLot Number
538925

References

Reference overview
Vane, J.R. 1985. Adv. Prostaglandin Thromboxane Leukotriene Res. 15, 11.
Moncada, S., et al. 1979. Pharmacol. Rev. 30, 293.
Cho, M.J. and Allen, M.A. 1978. Prostaglandins 15, 943.
Tateson, J.E., et al. 1977. Prostaglandins 13, 389.

Brochure

Title
Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
Bioactive Lipids Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-November-2009 JSW
SynonymsPGI₂, Prostacyclin
DescriptionPotent vasodilatory prostaglandin produced by the endothelium. Induces vasodilation, stimulates cAMP formation. Cytoprotective and fibrinolytic. Inhibits platelet aggregation by receptor mediated stimulation of adenylate cyclase.
FormCrystalline solid
CAS number61849-14-7
Chemical formulaC₂₀H₃₁O₅ · Na
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). This product is rapidly hydrolyzed in acidic solutions. The half-life at pH 7.48 is between 3.5 min and 10.5 min at 25°C. At pH 12 the half-life is ~6 days at 25°C. No loss of biological activity was observed at pH 9.37 for 48 h, when stored at 0°C.
Toxicity Harmful
ReferencesVane, J.R. 1985. Adv. Prostaglandin Thromboxane Leukotriene Res. 15, 11.
Moncada, S., et al. 1979. Pharmacol. Rev. 30, 293.
Cho, M.J. and Allen, M.A. 1978. Prostaglandins 15, 943.
Tateson, J.E., et al. 1977. Prostaglandins 13, 389.