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525185 Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem

The Phospholipase C Activator, m-3M3FBS, also referenced under CAS 200933-14-8, controls the biological activity of Phospholipase C. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: m-3M3FBS, 2,4,6-Trimethyl-N-(m-3-trifluoromethylphenyl)benzenesulfonamide

Primary Target: Phospholipase C (PLC)
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
200933-14-8C₁₆H₁₆F₃NO₂S

Products

Catalogue NumberPackaging Qty/Pack
525185-10MG Plastic ampoule 10 mg
Description
OverviewA novel sulfonamide compound that acts as a cell-permeable and specific activator of phospholipase C (PLC). Shown to stimulate the PLC-mediated intracellular Ca2+ release, inositol phosphates production, and superoxide generation in various cell types. It activates all PLC isotypes (β2, β3, γ1, γ2, and δ1) in vitro, but not heterotrimeric G proteins, PI 3-kinase, or PLD.
Catalogue Number525185
Brand Family Calbiochem®
Synonymsm-3M3FBS, 2,4,6-Trimethyl-N-(m-3-trifluoromethylphenyl)benzenesulfonamide
References
ReferencesBae, Y.S., et al. 2003. Mol. Pharmacol. 63, 1043.
Product Information
CAS number200933-14-8
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₆H₁₆F₃NO₂S
Chemical formulaC₁₆H₁₆F₃NO₂S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPhospholipase C (PLC)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
525185-10MG 04055977197150

Documentation

Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem Certificates of Analysis

TitleLot Number
525185

References

Reference overview
Bae, Y.S., et al. 2003. Mol. Pharmacol. 63, 1043.

Citations

Title
  • Eva Mortier, et al. (2005) Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions. The EMBO Journal 24, 2556-2565.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision26-August-2008 RFH
    Synonymsm-3M3FBS, 2,4,6-Trimethyl-N-(m-3-trifluoromethylphenyl)benzenesulfonamide
    DescriptionA cell-permeable and specific activator of phospholipase C (PLC). Reported to stimulate PLC-mediated intracellular Ca2+ release, inositol phosphate production, and superoxide generation in various cell types. Activates all PLC isotypes (β2, β3, γ1, &gamma2, and δ1) in vitro, but does not exhibit any effect on heterotrimeric G proteins, PI 3-kinase, or phospholipase D.
    FormOff-white solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number200933-14-8
    Chemical formulaC₁₆H₁₆F₃NO₂S
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMSO (7 mg/ml)
    Storage Protect from light
    +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
    Toxicity Carcinogenic / Teratogenic
    ReferencesBae, Y.S., et al. 2003. Mol. Pharmacol. 63, 1043.
    Citation
  • Eva Mortier, et al. (2005) Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions. The EMBO Journal 24, 2556-2565.
    		•