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524618 PIP3 Antagonist, PITenin-7 - CAS 1356060-65-5 - Calbiochem

The PIP3 Antagonist, PITenin-7 controls the biological activity of PIP3.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-Hydroxybiphenyl-3-ylcarbamothioyl)-3,5-dimethylbenzamide, Phosphatidylinositol-3,4,5-triphosphate Antagonist, PITenin-7, PIT-7, Akt Inhibitor XX, PDK1 Inhibitor V

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524618
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Overview

Key Spec Table

CAS #Empirical Formula
1356060-65-5C₂₂H₂₀N₂O₂S

Products

Catalogue NumberPackaging Qty/Pack
524618-10MG Glass bottle 10 mg
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Description
OverviewA cell-permeable DM-PIT-1 (Cat. No. 524619) analog that is more selective and potent than DM-PIT-1 against PH domain-mediated PIP3 (Cat. No. 524615) binding to Akt1 (IC50 = 13.4 and 27.1 µM, respectively) and PDK1 (IC50 = 52.3 and 80.5 µM, respectively), while being much less active than DM-PIT-1 against PIP3 GRP1 PH domain binding (12% vs 84% inhibition with 100 µM respective compound). PIT-7 is also shown to be more effective than DM-PIT-1 in inhibiting human glioblastoma U87MG survival (IC50 = 6.6 vs. 33.9 µM, respectively) and cellular Akt Ser473 phosphorylation in cultures in vitro.
Catalogue Number524618
Brand Family Calbiochem®
SynonymsN-(4-Hydroxybiphenyl-3-ylcarbamothioyl)-3,5-dimethylbenzamide, Phosphatidylinositol-3,4,5-triphosphate Antagonist, PITenin-7, PIT-7, Akt Inhibitor XX, PDK1 Inhibitor V
References
ReferencesMiao, B., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 20126.
Product Information
CAS number1356060-65-5
FormYellow-white semi-solid
Hill FormulaC₂₂H₂₀N₂O₂S
Chemical formulaC₂₂H₂₀N₂O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥95% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
524618-10MG 04055977197457