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526521 PIM1 Inhibitor III

The PIM1 Inhibitor III controls the biological activity of PIM1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

PIM1 Inhibitor III MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: PIM1
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₈H₂₃N₅O₅Ru
Description
OverviewThe racemic mixture of a pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a ATP-binding site-targeting, reversible, and highly potent inhibitor of PIM-1 (IC50 = 0.5 and 3 nM for the (S)- and (R)-enantiomer, respectively) with ∼10-fold selectivity over GSK-3α (IC50 = 15 and 20 nM for the (S)- and (R)-enantiomer, respectively).
Catalogue Number526521
Brand Family Calbiochem®
References
ReferencesBergman, H. and Meggers, E., 2006. Org. Lett. 8, 5465.
Product Information
ATP CompetitiveN
DeclarationSold for research purposes only, pursuant to an agreement with University of Pennsylvania.
FormPurple solid
Hill FormulaC₂₈H₂₃N₅O₅Ru
Chemical formulaC₂₈H₂₃N₅O₅Ru
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPIM1
Primary Target IC<sub>50</sub>0.5 and 3 nM for the (S)- and (R)-enantiomer, of PIM-1, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
526521 0

Documentation

PIM1 Inhibitor III SDS

Title

Safety Data Sheet (SDS) 

PIM1 Inhibitor III Certificates of Analysis

TitleLot Number
526521

References

Reference overview
Bergman, H. and Meggers, E., 2006. Org. Lett. 8, 5465.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-January-2008 JSW
DescriptionThe racemic mixture of a pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a ATP-binding site-targeting, reversible, and highly potent inhibitor of PIM-1 (IC50 = 0.5 and 3 nM for the (S)- and (R)-enantiomer, respectively) with ∼10-fold selectivity over GSK-3α (IC50 = 15 and 20 nM for the (S)- and (R)-enantiomer, respectively).
FormPurple solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₈H₂₃N₅O₅Ru
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (6 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesBergman, H. and Meggers, E., 2006. Org. Lett. 8, 5465.