Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

524611 PIKfyve Inhibitor - CAS 371942-69-7 - Calbiochem

The PIKfyve Inhibitor, also referenced under CAS 371942-69-7, controls the biological activity of PIKfyve. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3ʹ2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine carboxamide, PtdIns3P 5-KInase Inhibitor, YM201636

View Products on Sigmaaldrich.com
524611
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
371942-69-7C₂₅H₂₁N₇O₃

Products

Catalogue NumberPackaging Qty/Pack
524611-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable pyridofuropyrimidine compound that selectively inhibits mammalian type III PtdInsP kinase (IC50 = 33 nM and >5 µM using murine PIKfyve and yeast Fab1, respectively), while exhibiting much reduced activity against p110α (IC50 = 3.3 µM) and little activity against type IIγ PtdInsP kinase even at concentrations as high as 10 µM. Shown to block serum-induced PtdIns(3,5)P2 production in NIH3T3 cells (80% inhibition at 800 nM) and disrupt cellular endosomal transport in a reversible manner.
Catalogue Number524611
Brand Family Calbiochem®
Synonyms6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3ʹ2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine carboxamide, PtdIns3P 5-KInase Inhibitor, YM201636
References
ReferencesJefferies, H.B.J., et al. 2008. EMBO Reports 9, 164.
Product Information
CAS number371942-69-7
FormWhite solid
Hill FormulaC₂₅H₂₁N₇O₃
Chemical formulaC₂₅H₂₁N₇O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25

Do not breathe dust.
Avoid contact with skin and eyes.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
524611-5MG 04055977197426

Documentation

PIKfyve Inhibitor - CAS 371942-69-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PIKfyve Inhibitor - CAS 371942-69-7 - Calbiochem Certificates of Analysis

TitleLot Number
524611

References

Reference overview
Jefferies, H.B.J., et al. 2008. EMBO Reports 9, 164.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-January-2009 RFH
Synonyms6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3ʹ2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine carboxamide, PtdIns3P 5-KInase Inhibitor, YM201636
DescriptionA cell-permeable pyridofuropyrimidine compound that selectively inhibits mammalian type III PtdInsP kinase (IC50 = 33 nM and >5 µM using murine PIKfyve and yeast Fab1, respectively), while exhibiting much reduced activity against p110α (IC50 = 3.3 µM) and little activity against type IIγ PtdInsP kinase even at concentrations as high as 10 µM. Shown to block serum-induced PtdIns(3,5)P2 production in NIH3T3 cells (80% inhibition at 800 nM) and disrupt cellular endosomal transport in a reversible manner.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number371942-69-7
Chemical formulaC₂₅H₂₁N₇O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (1 mg/ml). Enhanced solubility in DMSO can be achieved by the addition of a small drop of TFA.
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesJefferies, H.B.J., et al. 2008. EMBO Reports 9, 164.