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513000 PD 98059 - CAS 167869-21-8 - Calbiochem

PD 98059, CAS 167869-21-8, is a cell-permeable, selective & reversible inhibitor of MAP Kinase Kinase (MEK). Inhibits MAP Kinase activation and subsequent phosphorylation of MAP Kinase substrates.

PD 98059 - CAS 167869-21-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2ʹ-Amino-3ʹ-methoxyflavone, MEK Inhibitor V

Primary Target: MAP kinase kinase (MEK)
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Overview

Key Spec Table

CAS #Empirical Formula
167869-21-8C₁₆H₁₃NO₃

Products

Catalogue NumberPackaging Qty/Pack
513000-10MG Plastic ampoule 10 mg
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513000-25MG Plastic ampoule 25 mg
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513000-5MG Glass bottle 5 mg
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Description
OverviewSelective, reversible, and cell-permeable inhibitor of MAP kinase kinase (MEK) that acts by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates. Pretreatment of PC-12 cells with PD 98059 completely blocks the 4-fold increase in MAP kinase activity produced by nerve growth factor (NGF; IC50 = 2 µM); however, it has no effect on NGF-dependent tyrosine phosphorylation of the p140trk receptor or its substrate Shc and does not block NGF-dependent activation of PI 3-kinase. Blocks LPS-induced activation of TNF-α gene expression. Inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. A 5 mg/ml solution of PD 98059 (Cat. No. 513001) in anhydrous DMSO is also available.
Catalogue Number513000
Brand Family Calbiochem®
Synonyms2ʹ-Amino-3ʹ-methoxyflavone, MEK Inhibitor V
References
ReferencesMeans, T.K., et al. 2000. J. Leukoc. Biol. 67, 885.
Kültz, D., et al. 1998. J. Biol. Chem. 273, 13645.
Dudley, D.T., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 7686.
Langlois, W.J., et al. 1995. J. Biol. Chem. 270, 25320.
Pang, L., et al. 1995. J. Biol. Chem. 270, 13585.
Waters, S.B., et al. 1995. J. Biol. Chem. 270, 20883.
Product Information
CAS number167869-21-8
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₁₆H₁₃NO₃
Chemical formulaC₁₆H₁₃NO₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetMAP kinase kinase (MEK)
Primary Target IC<sub>50</sub>2 µM against NGF-induced increase in MAP kinase activity
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
513000-10MG 04055977272109
513000-25MG 04055977272116
513000-5MG 07790788050917