Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

528824 PARP Inhibitor XIV - CAS 1104546-89-5 - Calbiochem

The PARP Inhibitor XIV, also referenced under CAS 1104546-89-5, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(1-Methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinoline-1,3-dione, BYK204165

View Products on Sigmaaldrich.com
528824
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1104546-89-5C₁₅H₁₂N₂O₂

Products

Catalogue NumberPackaging Qty/Pack
528824-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable isoquinolinedione compound that potently inhibits PARP-1 activity (pIC50 = 7.35; IC50 = 45 nM) in a NAD+-competitive and reversible manner, while affecting PPAR-2 activity with a 100-fold lower potency. Selectively inhibits PARP-1-mediated cellular PAR formation and is of little effect against PAR formation in fibroblasts derived from parp-1(-/-) mice. Its in vivo application is limited by a poor aqueous solubility (~9 µM).
Catalogue Number528824
Brand Family Calbiochem®
Synonyms4-(1-Methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinoline-1,3-dione, BYK204165
References
ReferencesEltze, T., et al. 2008. Mol. Pharmacol. 74, 1587.
Product Information
CAS number1104546-89-5
FormOrange solid
Hill FormulaC₁₅H₁₂N₂O₂
Chemical formulaC₁₅H₁₂N₂O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC (sum of two isomers)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
528824-10MG 04055977196641

Documentation

PARP Inhibitor XIV - CAS 1104546-89-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PARP Inhibitor XIV - CAS 1104546-89-5 - Calbiochem Certificates of Analysis

TitleLot Number
528824

References

Reference overview
Eltze, T., et al. 2008. Mol. Pharmacol. 74, 1587.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2011 RFH
Synonyms4-(1-Methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinoline-1,3-dione, BYK204165
DescriptionA cell-permeable isoquinolinedione compound that potently inhibits PARP-1 activity (pIC50 = 7.35; IC50 = 45 nM) in a NAD+-competitive and reversible manner, while affecting PPAR-2 activity with a 100-fold lower potency. Selectively inhibits PARP-1-mediated cellular PAR formation and is of little effect against PAR formation in fibroblasts derived from parp-1(-/-) mice. Its in vivo application is limited by a poor aqueous solubility (~9 µM).
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1104546-89-5
Chemical formulaC₁₅H₁₂N₂O₂
Structure formulaStructure formula
Purity≥97% by HPLC (sum of two isomers)
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesEltze, T., et al. 2008. Mol. Pharmacol. 74, 1587.