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532999 Orai1 Inhibitor, AnCoA4 - Calbiochem

AnCoA4 binds to the C-terminus region of Orai 1 and reduces its binding to STIM1 and blocks Ca2+ influx through the store operated calcium (SOC) channel (EC₅₀ = 880 nM).

Orai1 Inhibitor, AnCoA4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CRAC Inhibitor II

Primary Target: Orail1
532999
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₂H₁₈O₆

Products

Catalogue NumberPackaging Qty/Pack
5.32999.0001 Glass bottle 10 mg
Description
OverviewA cell-permeable, non-toxic, tricyclic chromone-fused analog that directly binds to the C-terminus region of Orai 1 and reduces its binding to STIM1 and blocks Ca2+ influx through the store operated calcium (SOC) channel (EC50 = 880 nM). Its binding to Orai 1 is localized to the region that controls channel gating and interaction with STIM1. Does not affect voltage-gated Ca2+ channels even at higher concentrations (~ 10 µM). Shown to be more effective if administered before STIM1 begins interacting with Orai 1. Also shown to inhibit the expression genes involved in T cell activation and blocks Jurkat T cell proliferation (~ 10 µM). Reduces lymphohistiocytic inflammation without causing any neutrophil and tissue damage.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number532999
Brand Family Calbiochem®
SynonymsCRAC Inhibitor II
References
ReferencesSadaghiani, A.M., et al. 2014. Chem. Biol. 21, 1278.
Product Information
FormPale yellow solid
Hill FormulaC₂₂H₁₈O₆
Chemical formulaC₂₂H₁₈O₆
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetOrail1
Purity≥96% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.32999.0001 04055977282023

Documentation

Orai1 Inhibitor, AnCoA4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Sadaghiani, A.M., et al. 2014. Chem. Biol. 21, 1278.

Brochure

Title
Neuroscience Solutions for productive research

Technical Info

Title
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
White Paper: Further considerations of antibody validation and usage.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-April-2015 JSW
SynonymsCRAC Inhibitor II
DescriptionA cell-permeable, non-toxic, tricyclic chromone-fused analog that directly binds to the C-terminus region of Orai 1 and reduces its binding to STIM1 and blocks Ca2+ influx through the store operated calcium (SOC) channel (EC50 = 880 nM). Its binding to Orai 1 is localized to the region that controls channel gating and interaction with STIM1. Does not affect voltage-gated Ca2+ channels even at higher concentrations (~ 10 µM). Shown to be more effective if administered before STIM1 begins interacting with Orai 1. Also shown to inhibit the expression genes involved in T cell activation and blocks Jurkat T cell proliferation (~ 10 µM). Reduces lymphohistiocytic inflammation without causing any neutrophil and tissue damage.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₂H₁₈O₆
Purity≥96% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSadaghiani, A.M., et al. 2014. Chem. Biol. 21, 1278.