Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

495604 Okadaic Acid, Prorocentrum sp. - CAS 78111-17-8 - Calbiochem

View Products on Sigmaaldrich.com
495604
  
Purchase on Sigma-Aldrich

Overview

Key Spec Table

CAS #Empirical Formula
78111-17-8C₄₄H₆₈O₁₃
Description
OverviewAn ionophore-like polyether derivative of a C38 fatty acid compound that has tumor promoting properties. Potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and protein phosphatase 2A (IC50 = 0.1 nM). Does not affect the activity of tyrosine phosphatases, alkaline phosphatases, or acid phosphatases. Useful for the study of protein phosphatases in cell extracts as well as in intact cells. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF7) and in myeloid cells but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Has marked contractile effects on smooth muscle and heart muscle. Implicated as causative agent of diarrhetic shellfish poisoning. A 250 µM (25 µg/124 µl) solution of Okadaic Acid, (Cat. No. 495609) in DMSO is also available.
Catalogue Number495604
Brand Family Calbiochem®
SynonymsOA
References
ReferencesGjertsen, B.T., et al. 1994. J. Cell Sci. 107, 3363.
Kiguchi, K., et al. 1994. Cell Growth Differentiation 5, 995.
Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
Kreienbuhl, P., et al. 1992. Blood 80, 2911.
Nomura, M., et al. 1992. Biochemistry 31, 11915.
Song, Q., et al. 1992. J. Cell Physiol. 153, 550.
Tada, Y., et al. 1992. Immunopharmacol. 24, 17.
Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
Cohen, P., and Cohen, P.T. 1989. J. Biol. Chem. 264, 21435.
Haystead, T.A., et al. 1989. Nature 337, 78.
Product Information
CAS number78111-17-8
ATP CompetitiveN
FormColorless glassy solid
Hill FormulaC₄₄H₆₈O₁₃
Chemical formulaC₄₄H₆₈O₁₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetProtein phosphatase
Primary Target IC<sub>50</sub>10-15 nM and 0.1 nM against protein phosphatase 1 and protein phosphatase 2A, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Safety Information according to GHS
RTECSAA8227800
Safety Information
R PhraseR: 23/24/25-38

Toxic by inhalation, in contact with skin and if swallowed.
Irritating to skin.
S PhraseS: 22-26-36/37/39-45

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
495604 0