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488004 Nodinitib-1 - Calbiochem

Nodinitib-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CID-1088438, 1-((4-Methylphenyl)sulfonyl)-1H-benzimidazol-2-amine, ML130, 1-(Toluene-4-sulfonyl)-1H-benzimidazol-2-ylamine, NOD1 Signaling Inhibitor, Nucleotide-binding Oligomerization Domain 1 Signaling Inhibitor

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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₄H₁₃N₃O₂S
Description
Overview

This product has been discontinued.



A cell-permeable aminobenzimidazole compound that acts as a potent, specific and reversible inhibitor of NOD1 (Nucleotide-binding Oligomerization Domain 1; NLRC1, CARD4, or CLR7.1)-induced NF-κB activation (IC50 = 0.56 µM, >20, and >20 by NOD1 ligand, NOD2 ligand and TNFα in HEK293T-NF-κB-luciferase cells, respectively). Shown to block phosphorylation and degradation of IκBα and MAPK signaling (5 µM in HCT-116 cells) with no effect on Akt pathway. Suggested to directly interact with NOD1, alter the conformation and suppress RIP2 trafficking, a NOD1-binding partner required for NF-κB induction.
Catalogue Number488004
Brand Family Calbiochem®
SynonymsCID-1088438, 1-((4-Methylphenyl)sulfonyl)-1H-benzimidazol-2-amine, ML130, 1-(Toluene-4-sulfonyl)-1H-benzimidazol-2-ylamine, NOD1 Signaling Inhibitor, Nucleotide-binding Oligomerization Domain 1 Signaling Inhibitor
References
ReferencesKhan, P.M., et al. 2011. ACS Med. Chem. Lett. 2, 780.
Correa, R.G., et al. 2011. Chem. Biol. 18, 825.
Product Information
FormWhite powder
Hill FormulaC₁₄H₁₃N₃O₂S
Chemical formulaC₁₄H₁₃N₃O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
488004 0

Documentation

Nodinitib-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Nodinitib-1 - Calbiochem Certificates of Analysis

TitleLot Number
488004

References

Reference overview
Khan, P.M., et al. 2011. ACS Med. Chem. Lett. 2, 780.
Correa, R.G., et al. 2011. Chem. Biol. 18, 825.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2012 JSW
SynonymsCID-1088438, 1-((4-Methylphenyl)sulfonyl)-1H-benzimidazol-2-amine, ML130, 1-(Toluene-4-sulfonyl)-1H-benzimidazol-2-ylamine, NOD1 Signaling Inhibitor, Nucleotide-binding Oligomerization Domain 1 Signaling Inhibitor
DescriptionA cell-permeable aminobenzimidazole compound that acts as a potent, specific and reversible inhibitor of NOD1 (Nucleotide-binding Oligomerization Domain 1; NLRC1, CARD4, or CLR7.1)-induced NF-κB activation (IC50 = 0.56 µM, >20, and >20 by NOD1 ligand, NOD2 ligand and TNFα in HEK293T-NF-κB-luciferase cells, respectively). Shown to block phosphorylation and degradation of IκBα and MAPK signaling (5 µM in HCT-116 cells) with no effect on Akt pathway. Suggested to directly interact with NOD1, alter the conformation and suppress RIP2 trafficking, a NOD1-binding partner required for NF-κB induction.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₄H₁₃N₃O₂S
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml; clear, colorless solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKhan, P.M., et al. 2011. ACS Med. Chem. Lett. 2, 780.
Correa, R.G., et al. 2011. Chem. Biol. 18, 825.