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533088 Monoacylglycerol Lipase Inhibitor, Cpd21 - Calbiochem

MAGL inhibitor, Monoacylglycerol Lipase Inhibitor

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MAGL Inhibitor, Cpd21

Primary Target: MAGL
533088
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₆H₂₆O₄
Description
Overview

This product has been discontinued.



A cell-permeable hexanoate ester compound that acts as a potent, selective, non-competitive, and reversible inhibitor of monoacylglycerol lipase (MAGL, Ki = 400 nM, IC50 = 240 nM for hydrolysis of 2- arachidonoylglycerol (2-AG). Displays good selectivity over a broad panel of related enzymes and does not bind to CB1 and CB2 cannabinoid receptors (Ki >10 µM). Shown to inhibit mouse brain MAGL (IC50 = 180 nM), but does not affect the activity of fatty acid amide hydrolaase (FAAH; IC50 = 59 µM) in any significant manner. Improves the course of experimental autoimmune encephalitis (EAE) murine model of multiple sclerosis (5 mg/kg/day, i.p. for 21 days) without inducing any undesirable CB1-agonist-like activity.
Catalogue Number533088
Brand Family Calbiochem®
SynonymsMAGL Inhibitor, Cpd21
References
ReferencesHernandez-Torres, G., et al. 2014. Angew Chem Int Ed Engl. 53, in press.
Product Information
FormOff-white solid
Hill FormulaC₂₆H₂₆O₄
Chemical formulaC₂₆H₂₆O₄
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetMAGL
Primary Target K<sub>i</sub>400 nM, IC₅₀
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
533088 0

Documentation

Monoacylglycerol Lipase Inhibitor, Cpd21 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Hernandez-Torres, G., et al. 2014. Angew Chem Int Ed Engl. 53, in press.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-March-2016 JSW
SynonymsMAGL Inhibitor, Cpd21
DescriptionA cell-permeable hexanoate ester compound that acts as a potent, selective, non-competitive, and reversible inhibitor of monoacylglycerol lipase (MAGL, Ki = 400 nM, IC50 = 240 nM for hydrolysis of 2- arachidonoylglycerol (2-AG). Displays good selectivity over a broad panel of related enzymes and does not bind to CB1 and CB2 cannabinoid receptors (Ki >10 µM). Shown to inhibit mouse brain MAGL (IC50 = 180 nM), but does not affect the activity of fatty acid amide hydrolaase (FAAH; IC50 = 59 µM) in any significant manner. Improves the course of experimental autoimmune encephalitis (EAE) murine model of multiple sclerosis (5 mg/kg/day, i.p. for 21 days) without inducing any undesirable CB1-agonist-like activity.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₆H₂₆O₄
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHernandez-Torres, G., et al. 2014. Angew Chem Int Ed Engl. 53, in press.