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475879 Monastrol - CAS 254753-54-3 - Calbiochem

A potent, cell-permeable, non-tubulin-interacting mitosis inhibitor.

Monastrol - CAS 254753-54-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I

Primary Target: Mitotic kinesin Eg5
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
254753-54-3C₁₄H₁₆N₂O₃S

Products

Catalogue NumberPackaging Qty/Pack
475879-1MG Plastic ampoule 1 mg
475879-5MG Plastic ampoule 5 mg
Description
OverviewA potent, cell-permeable, non-tubulin-interacting mitosis inhibitor. Arrests mammalian cells in mitosis with monopolar spindles. In vitro, it specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein involved in the assembly and maintenance of the mitotic spindle (IC50 = 14 µM).
Catalogue Number475879
Brand Family Calbiochem®
Synonyms4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I
References
ReferencesKapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
Mayer, T.U., et al. 1999. Science 286, 971.
Product Information
CAS number254753-54-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₄H₁₆N₂O₃S
Chemical formulaC₁₄H₁₆N₂O₃S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMitotic kinesin Eg5
Primary Target IC<sub>50</sub>14 µM against mitotic kinesin Eg5
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
475879-1MG 04055977203479
475879-5MG 04055977203486

Documentation

Monastrol - CAS 254753-54-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Monastrol - CAS 254753-54-3 - Calbiochem Certificates of Analysis

TitleLot Number
475879

References

Reference overview
Kapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
Mayer, T.U., et al. 1999. Science 286, 971.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
Synonyms4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I
DescriptionA potent, cell-permeable, nontubulin-interacting mitosis inhibitor. Arrests mammalian cells in mitosis with monopolar spindles. In vitro, it specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein involved in the assembly and maintenance of the mitotic spindle (IC50 = 14 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number254753-54-3
Chemical formulaC₁₄H₁₆N₂O₃S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
Mayer, T.U., et al. 1999. Science 286, 971.