475856 Sigma-AldrichMitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem
The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1.
More>> The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 3-(2,4-Dichloro-5-methoxy-phenyl)-2-thioxo-1H-quinazolin-4-one, Mitochondrial Division Dnm1/Drp1 ATPase Inhibitor
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 338967-87-6 | C₁₅H₁₀Cl₂N₂O₂S |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 475856-10MG | Plastic ampoule | 10 mg |
| Description | |
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| Overview | A cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures (IC50 = 10 and 50 µM in yeast and COS cultures, respectively) in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC50 < 10 µM) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- (Cat. Nos. 569396 and 569397) as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release. |
| Catalogue Number | 475856 |
| Brand Family | Calbiochem® |
| Synonyms | 3-(2,4-Dichloro-5-methoxy-phenyl)-2-thioxo-1H-quinazolin-4-one, Mitochondrial Division Dnm1/Drp1 ATPase Inhibitor |
| References | |
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| References | Cassidy-Stone A., et al. 2008. Dev. Cell 14, 193. |
| Product Information | |
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| CAS number | 338967-87-6 |
| Form | White solid |
| Hill Formula | C₁₅H₁₀Cl₂N₂O₂S |
| Chemical formula | C₁₅H₁₀Cl₂N₂O₂S |
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| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 475856-10MG | 07790788056377 |
Documentation
Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem SDS
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Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 475856 |
References
| Reference overview |
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| Cassidy-Stone A., et al. 2008. Dev. Cell 14, 193. |