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444170 Manumycin A, Streptomyces parvulus - CAS 52665-74-4 - Calbiochem

An antibiotic with antitumor properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Farnesyltransferase (FTAse)
444170
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
52665-74-4C₃₁H₃₈N₂O₇
Description
OverviewAn antibiotic with antitumor properties. A cell-permeable potent and selective inhibitor of farnesyltransferase (FTase; IC50 = 5 µM) compared to geranylgeranyltransferase I (GGTase I; IC50 = 180 µM). Manumycin acts as a competitive inhibitor of FTase with respect to farnesylpyrophosphate (FPP; Ki = 1.2 µM), but acts as a noncompetitive inhibitor with respect to the Ras acceptor protein. Reported to inhibit the growth and invasive activity of pancreatic cancer cells.
Catalogue Number444170
Brand Family Calbiochem®
References
ReferencesKainuma, O., et al. 1997. Pancreas 15, 379.
Nagase, T., et al. 1996. Int. J. Cancer 65, 620.
Hara, M., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 3333.
Hara, M., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2281.
Tamanoi, R. 1993. Trends Biochem. Sci. 18, 349.
Product Information
CAS number52665-74-4
ATP CompetitiveN
FormYellow to brown solid
Hill FormulaC₃₁H₃₈N₂O₇
Chemical formulaC₃₁H₃₈N₂O₇
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetFarnesyltransferase (FTAse)
Primary Target IC<sub>50</sub>5 µM against farnesyltransferase (FTase); 180 µM against geranylgeranyltransferase I (GGTase I)
Purity≥96% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
444170 0

Documentation

Manumycin A, Streptomyces parvulus - CAS 52665-74-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Manumycin A, Streptomyces parvulus - CAS 52665-74-4 - Calbiochem Certificates of Analysis

TitleLot Number
444170

References

Reference overview
Kainuma, O., et al. 1997. Pancreas 15, 379.
Nagase, T., et al. 1996. Int. J. Cancer 65, 620.
Hara, M., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 3333.
Hara, M., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2281.
Tamanoi, R. 1993. Trends Biochem. Sci. 18, 349.

Citations

Title
  • Karen E. Porter, et al. (2004) Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. Cardiovascular Research 61, 745-755.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision19-May-2009 JSW
    DescriptionAn antibiotic with antitumor properties. A potent and selective inhibitor of farnesyltransferase (FTase, IC50 = 5 µM) compared to geranyl-geranyltransferase I (GGTase, IC50 = 180 µM). Manumycin acts as a competitive inhibitor of FTase with respect to farnesylpyrophosphate (FPP, Ki = 1.2 µM), but as a noncompetitive inhibitor with respect to the Ras acceptor protein. Reported to inhibit the growth and invasive activity of pancreatic cancer cells.
    FormYellow to brown solid
    CAS number52665-74-4
    Chemical formulaC₃₁H₃₈N₂O₇
    Structure formulaStructure formula
    Purity≥96% by HPLC
    SolubilityDMSO (10 mg/ml), Methanol or Chloroform
    Storage Protect from light
    +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
    Toxicity Standard Handling
    ReferencesKainuma, O., et al. 1997. Pancreas 15, 379.
    Nagase, T., et al. 1996. Int. J. Cancer 65, 620.
    Hara, M., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 3333.
    Hara, M., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2281.
    Tamanoi, R. 1993. Trends Biochem. Sci. 18, 349.
    Citation
  • Karen E. Porter, et al. (2004) Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. Cardiovascular Research 61, 745-755.
    		•