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475846 MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Macrophage Migration Inhibitory Factor Antagonist III, 4-IPP, 4-Iodo-6-phenylpyrimidine

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
41270-96-6C₁₀H₇IN₂

Products

Catalogue NumberPackaging Qty/Pack
475846-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable iodo-pyrimidine compound that covalently modifies MIF N-terminal proline and exhibits higher MIF inhibitory potency than ISO-1 (Cat. No. 475837) in cell-free dopachrome tautomerase activity assays (IC50 ~5 vs. 50 µM, respectively, using recombinant human MIF) as well as in cell-based migration assays (50% vs 0% inhibition with respective inhibitor at 10 µM) and anchorage-independent growth (57% vs 0% inhibition with respective inhibitor at 10 µM) using human lung adenocarcinoma A549. Also shown to reduce A549 cellular active Rac1 population (50 µM, 16 h) in vitro and effectively decrease liver tautomerase activity by 50% in mice (1 mg/animal/day or ~50 mg/kg/day via i.p.) in vivo.
Catalogue Number475846
Brand Family Calbiochem®
SynonymsMacrophage Migration Inhibitory Factor Antagonist III, 4-IPP, 4-Iodo-6-phenylpyrimidine
References
ReferencesWinner, M., et al. 2008. Cancer Res. 68, 7253.
Product Information
CAS number41270-96-6
FormAmber solid
Hill FormulaC₁₀H₇IN₂
Chemical formulaC₁₀H₇IN₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
475846-10MG 04055977185010

Documentation

MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem Certificates of Analysis

TitleLot Number
475846

References

Reference overview
Winner, M., et al. 2008. Cancer Res. 68, 7253.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-March-2011 RFH
SynonymsMacrophage Migration Inhibitory Factor Antagonist III, 4-IPP, 4-Iodo-6-phenylpyrimidine
DescriptionA cell-permeable iodo-pyrimidine compound that covalently modifies MIF N-terminal proline and exhibits higher MIF inhibitory potency than ISO-1 (Cat. No. 475837) in cell-free dopachrome tautomerase activity assays (IC50 ~5 vs. 50 µM, respectively, using recombinant human MIF) as well as in cell-based migration assays (50% vs 0% inhibition with respective inhibitor at 10 µM) and anchorage-independent growth (57% vs 0% inhibition with respective inhibitor at 10 µM) using human lung adenocarcinoma A549. Also shown to reduce A549 cellular active Rac1 population (50 µM, 16 h) in vitro and effectively decrease liver tautomerase activity by 50% in mice (1 mg/animal/day or ~50 mg/kg/day via i.p.) in vivo.
FormAmber solid
Intert gas (Yes/No) Packaged under inert gas
CAS number41270-96-6
Chemical formulaC₁₀H₇IN₂
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWinner, M., et al. 2008. Cancer Res. 68, 7253.