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427218 Lactate Dehydrogenase A Inhibitor, FX11 - Calbiochem

Lactate Dehydrogenase A Inhibitor, FX11, CAS 213971-34-7, is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: LDH-A Inhibitor I, LDH-M Inhibitor I, LDHM Inhibitor I, LDHA Inhibitor I

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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
427218-10MG Glass bottle 10 mg
Description
OverviewA cell permeable, gossypol analog that acts as a selective, reversible, and NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA). Does not affect the activities of LDHB and glyceraldehyde-3-phosphate dehydrogenase even at higher concentrations. Shown to increase oxygen consumption, reactive oxygen species production, and cell death in P493 human lymphoma B cells. Also shown to reduce mitochondrial transmembrane potential and ATP levels and increase AMP kinase activity. Exhibits synergistic toxicity in P493 cells when combined with FK866 (Cat. No. 481908). Blocks the progression of human lymphoma and pancreatic cancer xenografts and when used in combination with FK866 it induces lymphoma regression.
Catalogue Number427218
Brand Family Calbiochem®
SynonymsLDH-A Inhibitor I, LDH-M Inhibitor I, LDHM Inhibitor I, LDHA Inhibitor I
References
ReferencesLe, A., et al. 2011. Proc Natl Acad Sci USA. 107, 2037.
Deck, L. M., et al. 1998. J Med Chem. 41, 3879.
Product Information
CAS number213971-34-7
FormWhite solid
Hill FormulaC₂₂H₂₂O₄
Chemical formulaC₂₂H₂₂O₄
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationLactate Dehydrogenase A Inhibitor, FX11, CAS 213971-34-7, is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA).
Biological Information
Primary TargetLDHA
Primary Target K<sub>i</sub>8 µ
Purity≥96% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
427218-10MG 04055977187403

Documentation

Lactate Dehydrogenase A Inhibitor, FX11 - Calbiochem Certificates of Analysis

TitleLot Number
427218

References

Reference overview
Le, A., et al. 2011. Proc Natl Acad Sci USA. 107, 2037.
Deck, L. M., et al. 1998. J Med Chem. 41, 3879.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-December-2013 JSW
SynonymsLDH-A Inhibitor I, LDH-M Inhibitor I, LDHM Inhibitor I, LDHA Inhibitor I
DescriptionA cell permeable, gossypol analog that acts as a selective, reversible, and NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA). Does not affect the activities of LDHB and glyceraldehyde-3-phosphate dehydrogenase even at higher concentrations. Shown to increase oxygen consumption, reactive oxygen species production, and cell death in P493 human lymphoma B cells. Also shown to reduce mitochondrial transmembrane potential and ATP levels and increase AMP kinase activity. Exhibits synergistic toxicity in P493 cells when combined with FK866 (Cat. No. 481908). Blocks the progression of human lymphoma and pancreatic cancer xenografts and when used in combination with FK866 it induces lymphoma regression.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number213971-34-7
Chemical formulaC₂₂H₂₂O₄
Structure formulaStructure formula
Purity≥96% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLe, A., et al. 2011. Proc Natl Acad Sci USA. 107, 2037.
Deck, L. M., et al. 1998. J Med Chem. 41, 3879.