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508408 InSolution™ Batimastat - CAS 130370-60-4 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide

Primary Target: MMPs
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
130370-60-4C₂₃H₃₁N₃O₄S₂

Products

Catalogue NumberPackaging Qty/Pack
5.08408.0001 Glass bottle 2 mg
Description
Catalogue Number508408
Brand Family Calbiochem®
Synonyms(4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide
References
ReferencesSchlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
Parvathy, S., et al. 1998. Biochemistry 37, 1680.
Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
Moss, M.L., et al. 1997. Nature 385, 733.
Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
Wang, X., et al. 1994. Cancer Res. 54, 4726.
Davies, B., et al. 1993. Cancer Res. 53, 2087.
Product Information
CAS number130370-60-4
FormLiquid
FormulationA 25 mM (2 mg/168 µL) sterile-filtered solution of Batimastat (Cat. No. 196440) in DMSO.
Hill FormulaC₂₃H₃₁N₃O₄S₂
Chemical formulaC₂₃H₃₁N₃O₄S₂
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMMPs
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.08408.0001 04055977261929

Documentation

InSolution™ Batimastat - CAS 130370-60-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Schlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
Parvathy, S., et al. 1998. Biochemistry 37, 1680.
Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
Moss, M.L., et al. 1997. Nature 385, 733.
Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
Wang, X., et al. 1994. Cancer Res. 54, 4726.
Davies, B., et al. 1993. Cancer Res. 53, 2087.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-December-2013 JSW
Synonyms(4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide
DescriptionA Marimastat (Cat. No. 444289) type of peptidyl hydroxamate-based inhibitor that potently inhibits a broad-spectrum of metalloproteinases, including MMP-1, MMP-2, MMP-3/stromelysin, MMP-7/matrilysin, MMP-9, ΔMT1 (MMP-14 without TM domain), ADAM8, and ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3, and 19 nM, respectively), by targeting both the substrate binding site and the active-site Zn2+, while being much less potent toward ACE (Angiotensin Converting Enzyme) or α-secretase (IC50 = 1.6 and 3.3 µM, respectively). Batimastat is widely used in studying the involvement of MMPs in cancinogenesis and non-cancer pathological processes both in cultures in vitro and in animals in vivo.
FormLiquid
FormulationA 25 mM (2 mg/168 µL) sterile-filtered solution of Batimastat (Cat. No. 196440) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number130370-60-4
Chemical formulaC₂₃H₃₁N₃O₄S₂
Structure formulaStructure formula
Purity≥97% by HPLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.
Toxicity Standard Handling
ReferencesSchlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
Parvathy, S., et al. 1998. Biochemistry 37, 1680.
Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
Moss, M.L., et al. 1997. Nature 385, 733.
Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
Wang, X., et al. 1994. Cancer Res. 54, 4726.
Davies, B., et al. 1993. Cancer Res. 53, 2087.