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401489 IKK Inhibitor X - CAS 431898-65-6 - Calbiochem

The IKK Inhibitor X, also referenced under CAS 431898-65-6, controls the biological activity of IKK. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(6-Chloro-9H-β-carbolin-8-yl)nicotinamide, PS-1145

Primary Target: IKK
401489
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
431898-65-6C₁₇H₁₁ClN₄O
Description
Overview

This product has been discontinued.



A cell-permeable β-carboline compound that displays anti-inflammatory properties. Acts as a potent, ATP-competitive, and reversible inhibitor of IKK (IC50 = 88 nM) with selectivity over 14 other commonly studied kinases (IC50 > 100 µM), including NF-κB inducing kinase. Blocks cellular IκBα phosphorylation and NF-κB activation (EC50 = 5 µM in TNF-α-treated HeLa cells) in vitro and reduces TNF-α release in plasma of LPS-challenged mice in vivo (50 mg/ml, p.o.).
Catalogue Number401489
Brand Family Calbiochem®
SynonymsN-(6-Chloro-9H-β-carbolin-8-yl)nicotinamide, PS-1145
References
ReferencesCatley, M.C., et al. 2006. Mol. Pharmacol. 70, 697.
Wen, D., et al. 2006. J. Pharm. Exp. Ther. 317, 989.
Castro, A.C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 2419.
Hideshima, T., et al. 2002. J. Biol. Chem. 277, 16639.
Product Information
CAS number431898-65-6
ATP CompetitiveY
FormYellow solid
Hill FormulaC₁₇H₁₁ClN₄O
Chemical formulaC₁₇H₁₁ClN₄O
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetIKK
Primary Target IC<sub>50</sub>88 nM against IKK
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
401489 0

Documentation

IKK Inhibitor X - CAS 431898-65-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

IKK Inhibitor X - CAS 431898-65-6 - Calbiochem Certificates of Analysis

TitleLot Number
401489

References

Reference overview
Catley, M.C., et al. 2006. Mol. Pharmacol. 70, 697.
Wen, D., et al. 2006. J. Pharm. Exp. Ther. 317, 989.
Castro, A.C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 2419.
Hideshima, T., et al. 2002. J. Biol. Chem. 277, 16639.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
SynonymsN-(6-Chloro-9H-β-carbolin-8-yl)nicotinamide, PS-1145
DescriptionA cell-permeable β-carboline compound that displays anti-inflammatory properties. Acts as a potent, ATP-competitive, and reversible inhibitor of IKK (IC50 =88 nM) with selectivity over 14 other commonly studied kinases (IC50 > 100 µM), including NF-κB inducing kinase. Blocks cellular IκBα phosphorylation and NF-κB activation (EC50 = 5 µM in TNF-α-treated HeLa cells) in vitro and reduces TNF-α release in plasma of LPS-challenged mice in vivo (50 mg/ml p.o.).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number431898-65-6
Chemical formulaC₁₇H₁₁ClN₄O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesCatley, M.C., et al. 2006. Mol. Pharmacol. 70, 697.
Wen, D., et al. 2006. J. Pharm. Exp. Ther. 317, 989.
Castro, A.C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 2419.
Hideshima, T., et al. 2002. J. Biol. Chem. 277, 16639.