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400090 IC261 - CAS 186611-52-9 - Calbiochem

A cell-permeable, reversible, potent and selective inhibitor of casein kinase (CK1) that inhibits CK1δ (IC₅₀ = 0.7-1.3 µM) and CK1ε (IC₅₀ = 0.6-1.4 µM) isozymes.

IC261 - CAS 186611-52-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-[(2,4,6-Trimethoxyphenyl)methylidenyl]-indolin-2-one, SU5607, Casein Kinase I Inhibitor VI

Primary Target: CK1δ
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
186611-52-9C₁₈H₁₇NO₄
Description
OverviewA cell-permeable, reversible, potent and selective inhibitor of casein kinase (CK1) that inhibits CK1δ (IC50 = 0.7-1.3 µM) and CK1ε (IC50 = 0.6-1.4 µM) isozymes. Also inhibits CK1α1 at much higher concentrations (IC50 = 11-21 µM). The inhibition is competitive with respect to ATP. Only weakly inhibits PKA, p34cdc2, and p55fyn (IC50s > 100 µM). At low micromolar concentrations, IC261 inhibits cytokinesis causing a transient mitotic arrest.
Catalogue Number400090
Brand Family Calbiochem®
Synonyms3-[(2,4,6-Trimethoxyphenyl)methylidenyl]-indolin-2-one, SU5607, Casein Kinase I Inhibitor VI
References
ReferencesBehrend, L., et al. 2000. Oncogene 19, 5303.
Mashhoon, N., et al. 2000. J. Biol. Chem. 275, 20052.
Knippschild, U., et al. 1997. Oncogene 15, 1727.
Product Information
CAS number186611-52-9
ATP CompetitiveY
FormYellow solid
Hill FormulaC₁₈H₁₇NO₄
Chemical formulaC₁₈H₁₇NO₄
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCK1δ
Primary Target IC<sub>50</sub>0.7-1.3 µM, 0.6-1.4 µM, against CK1δ and CK1ε isozymes, respectively
Purity≥95% by HPLC (sum of two isomers)
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C when stored under an inert gas.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
400090 0

Documentation

IC261 - CAS 186611-52-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

IC261 - CAS 186611-52-9 - Calbiochem Certificates of Analysis

TitleLot Number
400090

References

Reference overview
Behrend, L., et al. 2000. Oncogene 19, 5303.
Mashhoon, N., et al. 2000. J. Biol. Chem. 275, 20052.
Knippschild, U., et al. 1997. Oncogene 15, 1727.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-December-2009 RFH
Synonyms3-[(2,4,6-Trimethoxyphenyl)methylidenyl]-indolin-2-one, SU5607, Casein Kinase I Inhibitor VI
DescriptionA cell-permeable, reversible, potent and selective inhibitor of Casein Kinase (CK1) that inhibits the CK1δ (IC50 = 0.7-1.3 µM) and CK1ε (IC50 = 0.6-1.4 µM) isozymes. Also inhibits CK1α1 at much higher concentrations (IC50 = 11-21 µM). The inhibition is competitive with respect to ATP. Has only a trivial effect on p34cdc2 and p55fyn (IC50s >100 µM). Blocks the phosphorylation of p53 by CK1δ and CK1ε, thereby modulating p53's effect on the cell cycle. At low micromolar concentrations, IC261 inhibits cytokinesis causing a transient mitotic arrest.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number186611-52-9
Chemical formulaC₁₈H₁₇NO₄
Structure formulaStructure formula
Purity≥95% by HPLC (sum of two isomers)
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C when stored under an inert gas.
Toxicity Standard Handling
ReferencesBehrend, L., et al. 2000. Oncogene 19, 5303.
Mashhoon, N., et al. 2000. J. Biol. Chem. 275, 20052.
Knippschild, U., et al. 1997. Oncogene 15, 1727.