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3779 Histamine, Free Base - CAS 51-45-6 - Calbiochem

A potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(4-Imidazolyl)ethylamine

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
51-45-6C₅H₉N₃

Products

Catalogue NumberPackaging Qty/Pack
3779-1GM Glass bottle 1 gm
Description
OverviewA potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase. Formed by the decarboxylation of L-histidine. Activation of histamine H1 receptors leads to Ca2+ mobilization, whereas histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Stimulated time- and concentration-dependent increase in p38 and p42/p44 MAP kinases in DDT(1) MF2 cells.
Catalogue Number3779
Brand Family Calbiochem®
Synonyms2-(4-Imidazolyl)ethylamine
References
ReferencesRobinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.
Product Information
CAS number51-45-6
FormWhite solid
Hill FormulaC₅H₉N₃
Chemical formulaC₅H₉N₃
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSMS1050000
Safety Information
R PhraseR: 22-36/37/38-42/43

Harmful if swallowed.
Irritating to eyes, respiratory system and skin.
May cause sensitization by inhalation and skin contact.
S PhraseS: 26-36/37-22

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing and gloves.
Do not breathe dust.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
3779-1GM 07790788049744

Documentation

Histamine, Free Base - CAS 51-45-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Histamine, Free Base - CAS 51-45-6 - Calbiochem Certificates of Analysis

TitleLot Number
3779

References

Reference overview
Robinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-June-2011 JSW
Synonyms2-(4-Imidazolyl)ethylamine
DescriptionA potent vasodilator found in normal tissues and blood. Formed by the decarboxylation of L-histidine. Activates nitric oxide synthase (NOS), resulting in the release of nitric oxide. Activation of histamine H1 receptors leads to Ca2+ mobilization; whereas, histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number51-45-6
RTECSMS1050000
Chemical formulaC₅H₉N₃
Structure formulaStructure formula
Purity≥97% by TLC
SolubilityH₂O (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
Merck USA index14, 4719
ReferencesRobinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.