373278 Sigma-AldrichHh Signaling Antagonist XII, MRT-83 - Calbiochem
Recommended Products
Overview
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Key Spec Table
| Empirical Formula |
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| C₃₁H₃₀N₄O₅ |
| Description | |
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| Overview | This product has been discontinued. A cell-permeable acylguanidine compound that is shown to block Hh signaling and act as a potent, reversible and high-affinity Smo (Smoothened) antagonist. Displays 20-60 -fold greater potency than Cyclopamine (Cat. No. 239803) and competitively inhibits bodipy-cyclopamine binding to Smo (IC50 = 4.6 and 14 nM in HEK293-hSMO and HEK293-mSMO cells, respectively). Represses ShhN (N-myristoylated Shh) signaling (IC50 = 15 nM for Gli-dependent luciferase activity in Shh-light2 cells) and SAG-(Cat. Nos. 566660 & 566661) induced C3H10T1/2 cell differentiation (IC50 = 10 nM in an alkaline phosphatase activity assay). Inhibits ShhN (3 nM) and SAG (10 nM)-mediated proliferation of rat cerebellar granule cell precursors (IC50 ~ 3 and 6 nM, respectively). |
| Catalogue Number | 373278 |
| Brand Family | Calbiochem® |
| Synonyms | N-(2-Methyl-5-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)-(1,1ʹ-biphenyl)-4-carboxamide |
| References | |
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| References | Roudaut, H., et al. 2011. Mol. Pharmacol. 79, 453. |
| Product Information | |
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| Form | Yellowish-white solid |
| Hill Formula | C₃₁H₃₀N₄O₅ |
| Chemical formula | C₃₁H₃₀N₄O₅ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥98% by HPLC |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 373278 | 0 |
Documentation
Hh Signaling Antagonist XII, MRT-83 - Calbiochem SDS
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Hh Signaling Antagonist XII, MRT-83 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 373278 |
References
| Reference overview |
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| Roudaut, H., et al. 2011. Mol. Pharmacol. 79, 453. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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