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385570 Heat Shock Factor 1 Inhibitor, KRIBB11 - CAS 342639-96-7 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
342639-96-7C₁₃H₁₂N₆O₂

Products

Catalogue NumberPackaging Qty/Pack
385570-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable 2,6-diaminopyridine compound that interacts with HSF1 in a reversible manner and prevents HSF1 from recruiting p-TEFb to the hsp70 promoter site (IC50 ≤3 µM in HCT-116 ChIP assays), a critical step for heat shock-induced transcription activation (IC50 <1, <3, <5, and <10 µM, respectively, against reporter, HSP47, HSP27, and HSP70 transcription in HCT-116 cultures). Reported to exhibit antiproliferation activity against several cancer cultures in vitro (IC50 from 3 to 8 µM) and effectively suppress HCT-116-derived tumor growth in mice in vivo (50 mg/kg i.p.).
Catalogue Number385570
Brand Family Calbiochem®
SynonymsN²-(1H-Indazol-5-yl)-N⁶-methyl-3-nitropyridine-2,6-diamine , HSF1 Inhibitor, KRIBB11, Heat Shock Protein Inhibitor III, p-TEFb hsp70 Promoter Recruitment Inhibitor, Hsp70 Induction Inhibitor II
References
ReferencesYoon, Y.J., et al. 2010. J. Biol. Chem. 286, 1737.
Product Information
CAS number342639-96-7
FormOrange-yellow solid
Hill FormulaC₁₃H₁₂N₆O₂
Chemical formulaC₁₃H₁₂N₆O₂
Structure formula ImageStructure formula Image
Quality LevelMQ200
Biological Information
Purity≥98% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
385570-10MG 04055977190274