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373210 HDL Receptor SR-BI Inhibitor, BLT-1 - CAS 321673-30-7 - Calbiochem

The HDL Receptor SR-BI Inhibitor, BLT-1, also referenced under CAS 321673-30-7, controls the biological activity of HDL Receptor SR-B. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Block Lipid Transport-1, 2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20

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373210
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
321673-30-7C₁₂H₂₃N₃S

Products

Catalogue NumberPackaging Qty/Pack
373210-25MG 25 mg
Description
OverviewA cell-permeable thiosemicarbazone copper chelator that potently blocks the HDL receptor SR-BI- (scavenger receptor, class B, type I) mediated lipid uptake (IC50 = 21 and 57 nM against DiI and CE uptake, respectively, from DiI-HDL and CE-HDL using hamster ldlA-7 cells expressing murine SR-BI) in a reversible manner, while exerting little effect toward intracellular membrane trafficking or cytoskeletal organization. BLT-1 chelates Cu+2 in a 2:1 stoichiometric ratio and a half molar equivalent of CuCl2 is shown to fully prevent zebrafish embryos from BLT-1-induced development defects, while BLT-1 can likewise be used to chelate excess amount of copper (>4 µM) and rescue embryos from copper toxicity.
Catalogue Number373210
Brand Family Calbiochem®
SynonymsBlock Lipid Transport-1, 2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20
References
ReferencesNieland, T.J.F., et al. 2008. Biochemistry 47, 460.
Raldua, D., and Babin, P.J. 2007. Toxicol. Lett. 175, 1.
Nieland, T.J.F., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 15422.
Peterson, R.T., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 12965.
Product Information
CAS number321673-30-7
FormWhite solid
Hill FormulaC₁₂H₂₃N₃S
Chemical formulaC₁₂H₂₃N₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
373210-25MG 04055977191608

Documentation

HDL Receptor SR-BI Inhibitor, BLT-1 - CAS 321673-30-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

HDL Receptor SR-BI Inhibitor, BLT-1 - CAS 321673-30-7 - Calbiochem Certificates of Analysis

TitleLot Number
373210

References

Reference overview
Nieland, T.J.F., et al. 2008. Biochemistry 47, 460.
Raldua, D., and Babin, P.J. 2007. Toxicol. Lett. 175, 1.
Nieland, T.J.F., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 15422.
Peterson, R.T., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 12965.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsBlock Lipid Transport-1, 2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20
DescriptionA cell-permeable thiosemicarbazone copper chelator that potently blocks the HDL receptor SR-BI- (scavenger receptor, class B, type I) mediated lipid uptake (IC50 = 21 and 57 nM against DiI and CE uptake, respectively, from DiI-HDL and CE-HDL using hamster ldlA-7 cells expressing murine SR-BI) in a reversible manner, while exerting little effect toward intracellular membrane trafficking or cytoskeletal organization. BLT-1 chelates Cu+2 in a 2:1 stoichiometric ratio and a half molar equivalent of CuCl2 is shown to fully prevent zebrafish embryos from BLT-1-induced development defects, while BLT-1 can likewise be used to chelate excess amount of copper (>4 µM) and rescue embryos from copper toxicity.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number321673-30-7
Chemical formulaC₁₂H₂₃N₃S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesNieland, T.J.F., et al. 2008. Biochemistry 47, 460.
Raldua, D., and Babin, P.J. 2007. Toxicol. Lett. 175, 1.
Nieland, T.J.F., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 15422.
Peterson, R.T., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 12965.