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346006 Glucagon-Like Peptide 1 Receptor Agonist - CAS 281209-71-0 - Calbiochem

Glucagon-Like Peptide 1 Receptor Agonist, CAS 281209-71-0, modulates GLP-1 binding & induces cAMP production in BHK membranes. Potentiates glucose-dependent insulin release in WT pancreatic islets.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GLP-1R Agonist, 6,7-Dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
281209-71-0C₁₃H₁₅Cl₂N₃O₂S
Description
Overview

This product has been discontinued.



A nonpeptidic quinoxaline compound that acts as a GLP-1R agonist and an allosteric modulator of GLP-1 binding. Shown to induce GLP-1R-mediated cAMP production in BHK plasma membrane preparations (EC50 = 101 nM) and potentiate glucose-dependent insulin release in pancreatic islets derived from wild-type, but not GLP-1R -/-, mice. Unlike GLP-1, its biological activity is not inhibited by orthosteric antagonists such as Exendin.
Catalogue Number346006
Brand Family Calbiochem®
SynonymsGLP-1R Agonist, 6,7-Dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline
References
ReferencesKnudsen, L. B., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 937.
Product Information
CAS number281209-71-0
FormYellow solid
Hill FormulaC₁₃H₁₅Cl₂N₃O₂S
Chemical formulaC₁₃H₁₅Cl₂N₃O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationGlucagon-Like Peptide 1 Receptor Agonist, CAS 281209-71-0, modulates GLP-1 binding & induces cAMP production in BHK membranes. Potentiates glucose-dependent insulin release in WT pancreatic islets.
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
346006 0

Documentation

Glucagon-Like Peptide 1 Receptor Agonist - CAS 281209-71-0 - Calbiochem Certificates of Analysis

TitleLot Number
346006

References

Reference overview
Knudsen, L. B., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 937.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-April-2011 RFH
SynonymsGLP-1R Agonist, 6,7-Dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline
DescriptionA nonpeptidic quinoxaline compound that acts as a GLP-1R agonist and an allosteric modulator of GLP-1 binding. Shown to induce GLP-1R-mediated cAMP production in BHK plasma membrane preparations (EC50 = 101 nM) and potentiate glucose-dependent insulin release in pancreatic islets derived from wild-type, but not GLP-1R -/-, mice. Unlike GLP-1, its biological activity is not inhibited by orthosteric antagonists such as Exendin.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number281209-71-0
Chemical formulaC₁₃H₁₅Cl₂N₃O₂S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (20 mg/ml) or Ethanol (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesKnudsen, L. B., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 937.