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506216 Gap Junction Enhancer, PQ7 - Calbiochem

Gap Junction Enhancer, PQ7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
506216
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₃H₁₉F₃N2O₃
Description
Overview

This product has been discontinued.



A cell-permeable quinoline derived compound with low toxicity that enhances gap junctional activity by about 16-fold (at ~500 nM) in T47D breast cancer cells and thereby potentiates the effect of chemotherapeutic agents. Blocks T47D cell colony formation (IC50 = 100 nM) and reduce the growth of T47D xenograft tumors by 100% in Nu/Nu mice. Increases caspase-3, - 8, and -9 expression by 1.6, 2.8, and 3.8-fold, respectively to induce apoptotic cell death. Can work synergistically with cisplatin to reduce or totally eliminate tumor growth. Increases the expression of connexins 26, 32, and 43 to allow more efficient trafficking of cisplatin.
Catalogue Number506216
Brand Family Calbiochem®
References
ReferencesShishido, S.N., et al. 2013. PLos One. 8, e67174.
Shishido, S.N., et al. 2012. PLos One. 7,e444963.
Heiniger, B., et al. 2010. Anticancer Res. 30, 3927.
Shi, A., et al. 2008. Bioor. Med. Chem. Lett. 18, 3364.
Product Information
FormTan powder
Hill FormulaC₂₃H₁₉F₃N2O₃
Chemical formulaC₂₃H₁₉F₃N2O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target IC<sub>50</sub>100 nM
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
506216 0

Documentation

Gap Junction Enhancer, PQ7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Shishido, S.N., et al. 2013. PLos One. 8, e67174.
Shishido, S.N., et al. 2012. PLos One. 7,e444963.
Heiniger, B., et al. 2010. Anticancer Res. 30, 3927.
Shi, A., et al. 2008. Bioor. Med. Chem. Lett. 18, 3364.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-December-2013 JSW
DescriptionA cell-permeable quinoline derived compound with low toxicity that enhances gap junctional activity by about 16-fold (at ~500 nM) in T47D breast cancer cells and thereby potentiates the effect of chemotherapeutic agents. Blocks T47D cell colony formation (IC50 = 100 nM) and reduce the growth of T47D xenograft tumors by 100% in Nu/Nu mice. Increases caspase-3, - 8, and -9 expression by 1.6, 2.8, and 3.8-fold, respectively to induce apoptotic cell death. Can work synergistically with cisplatin to reduce or totally eliminate tumor growth. Increases the expression of connexins 26, 32, and 43 to allow more efficient trafficking of cisplatin.
FormTan powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₃H₁₉F₃N2O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesShishido, S.N., et al. 2013. PLos One. 8, e67174.
Shishido, S.N., et al. 2012. PLos One. 7,e444963.
Heiniger, B., et al. 2010. Anticancer Res. 30, 3927.
Shi, A., et al. 2008. Bioor. Med. Chem. Lett. 18, 3364.