361549 Sigma-AldrichGSK-3β Inhibitor VIII - CAS 487021-52-3 - Calbiochem
GSK-3β Inhibitor VIII, CAS 487021-52-3, is a cell-permeable, potent inhibitor of GSK-3 (IC50 = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38 nM).
More>> GSK-3β Inhibitor VIII, CAS 487021-52-3, is a cell-permeable, potent inhibitor of GSK-3 (IC50 = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38 nM). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: AR-A014418, N-(4-Methoxybenzyl)-Nʹ-(5-nitro-1,3-thiazol-2-yl)urea
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 487021-52-3 | C₁₂H₁₂N₄O₄S |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 361549-5MG | Plastic ampoule | 5 mg |
| Description | |
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| Overview | A cell-permeable thiazole-containing urea compound that acts as a potent inhibitor of GSK-3. Shown to inhibit GSK-3β with high potency (IC50 = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38 nM). Specificity has been reported using a panel of 28 different kinases, including Cdk2 and Cdk5 (IC50 > 100 µM). Shown to prevent tau phosphorylation at a GSK-3-specific site. Also shown to protect neuronal cells against Aβ-mediated neurodegeneration in vitro and reduce tauopathy in mice in vivo (30 µmol/kg delivered with 40% PEG400 and 40% dimethylacetamide in water). Caution: Do not use delivering vehicles containing dimethylamine for in vivo studies, as it is highly toxic to animals. A 25 mM (5 mg/649 µl) solution of GSK-3β Inhibitor VIII (Cat. No. 361557) in DMSO is also available. |
| Catalogue Number | 361549 |
| Brand Family | Calbiochem® |
| Synonyms | AR-A014418, N-(4-Methoxybenzyl)-Nʹ-(5-nitro-1,3-thiazol-2-yl)urea |
| References | |
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| References | Noble, W., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 6990. Bhat, R., et al. 2003. J. Biol. Chem. 278, 45937. |
| Product Information | |
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| CAS number | 487021-52-3 |
| ATP Competitive | Y |
| Form | Yellow solid |
| Hill Formula | C₁₂H₁₂N₄O₄S |
| Chemical formula | C₁₂H₁₂N₄O₄S |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
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| Application | GSK-3β Inhibitor VIII, CAS 487021-52-3, is a cell-permeable, potent inhibitor of GSK-3 (IC50 = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38 nM). |
| Biological Information | |
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| Primary Target | Gsk-3β |
| Primary Target IC<sub>50</sub> | 104 nM against GSK-3β |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 361549-5MG | 04055977214055 |
Documentation
GSK-3β Inhibitor VIII - CAS 487021-52-3 - Calbiochem SDS
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GSK-3β Inhibitor VIII - CAS 487021-52-3 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 361549 |
References
| Reference overview |
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| Noble, W., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 6990. Bhat, R., et al. 2003. J. Biol. Chem. 278, 45937. |