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331500 Etazolate, Hydrochloride

Etazolate, Hydrochloride MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-Ethyl-4-[(1-methylethylidene)hydrazino]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic Acid Ethyl Ester, HCl, SQ20009

331500
  
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Overview

Replacement Information
Description
Overview

This product has been discontinued.

We apologize for the inconvenience, but we do not currently have an alternative product. For related products, please refer to our complete listing of phosphodiesterase inhibitors.





A selective inhibitor of c-AMP-specific phosphodiesterase (PDE IV; IC50 = 2 µM). Also inhibits TNF-α production in cardiac tissue (IC50 = 2.1 µM).
Catalogue Number331500
Brand Family Calbiochem®
Synonyms1-Ethyl-4-[(1-methylethylidene)hydrazino]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic Acid Ethyl Ester, HCl, SQ20009
References
ReferencesBergman, M.R., and Holycross, B.J. 1996. J. Pharmacol. Exp. Therap. 279, 247. Tomes, C., et al. 1993. Cell Signal. 5, 615. Ahluwalia, G.S., and Rhoads, A.R. 1982. Biochem. Pharmacol. 31, 665.
Product Information
CAS number51022-77-6
FormPale yellow solid
Hill FormulaC₁₄H₁₉N₅O₂ · HCl
Chemical formulaC₁₄H₁₉N₅O₂ · HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetPDE 4
Primary Target IC<sub>50</sub>2 µM
Secondary targetTNF-α production in cardiac tissue (IC₅₀ = 2.1 µM)
Purity≥98% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
331500 0

Documentation

Etazolate, Hydrochloride Certificates of Analysis

TitleLot Number
331500

References

Reference overview
Bergman, M.R., and Holycross, B.J. 1996. J. Pharmacol. Exp. Therap. 279, 247. Tomes, C., et al. 1993. Cell Signal. 5, 615. Ahluwalia, G.S., and Rhoads, A.R. 1982. Biochem. Pharmacol. 31, 665.

Brochure

Title
Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-June-2008 RFH
Synonyms1-Ethyl-4-[(1-methylethylidene)hydrazino]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic Acid Ethyl Ester, HCl, SQ20009
DescriptionA selective cAMP-specific phosphodiesterase (PDE IV) inhibitor (IC50 = 2 µM). Also inhibits TNF-α production in cardiac tissue (IC50 = 2.07 µM).
FormPale yellow solid
CAS number51022-77-6
Chemical formulaC₁₄H₁₉N₅O₂ · HCl
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityH₂O (25 mg/ml)
Storage +15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Toxicity Irritant
ReferencesBergman, M.R., and Holycross, B.J. 1996. J. Pharmacol. Exp. Therap. 279, 247. Tomes, C., et al. 1993. Cell Signal. 5, 615. Ahluwalia, G.S., and Rhoads, A.R. 1982. Biochem. Pharmacol. 31, 665.