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05-23-3800 Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
117399-94-7C₁₀₉H₁₅₉N₂₅O₃₂S₅

Products

Catalogue NumberPackaging Qty/Pack
05-23-3800-0.1MG Plastic ampoule .1 mg
05-23-3800-0.5MG Plastic ampoule .5 mg
05-23-3800-1MG Plastic ampoule 1 mg
Description
OverviewA 21-amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
Catalogue Number05-23-3800
Brand Family Calbiochem®
SynonymsET-1, CSCSSLMDKECVYFCHLDIIW
References
ReferencesCesari, M., et al. 1996. Am. Heart J. 132, 1236.
Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
Yanagisawa, M., et al. 1988. Nature 332, 411.
Product Information
CAS number117399-94-7
ATP CompetitiveN
FormWhite to off-white solid
FormulationSupplied as an acetate salt.
Hill FormulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
Chemical formulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
ReversibleN
Sold on the basis of peptide contentY
Quality LevelMQ100
Biological Information
Primary TargetPotent vasoconstrictive action
Purity≥96% by HPLC
Physicochemical Information
Cell permeableN
Peptide ContentY
Peptide SequenceH-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Global Trade Item Number
Catalogue Number GTIN
05-23-3800-0.1MG 04055977226775
05-23-3800-0.5MG 04055977226782
05-23-3800-1MG 04055977226799