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324629 Eg5 Inhibitor VI - Calbiochem

The Eg5 Inhibitor VI controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.

Eg5 Inhibitor VI - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4ʹ-(Trifluoromethyl)-4-biphenyl)sulfamide, KSP Inhibitor VI

324629
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₃H₁₁F₃N₂O₂S
Description
Overview

This product has been discontinued.



A cell-permeable biphenylsulfamide compound that acts as a potent, reversible, and ATP-competitive inhibitor of Eg5/KSP ATPase activity (IC50 = 18 nM) with reactivity against both wild-type and the D130V mutant (Ki = 6.2 nM and 7 nM, respectively) in cell-free assays. Due to a higher ATP binding affinity of the WT enzyme, the inhibitor exhibits a much weaker antiproliferative activity against WT-expressing cells in cultures (IC50 = 5.4 and 403 nM, using HCT116 D130V and HCT116, respectively) and its in vivo antitumor efficacy has only been demonstrated in HCT116 D130V xenografed mice, but not mice with WT KSP-bearing Colo205.
Catalogue Number324629
Brand Family Calbiochem®
SynonymsN-(4ʹ-(Trifluoromethyl)-4-biphenyl)sulfamide, KSP Inhibitor VI
References
ReferencesParrish, C.A., et al. 2007. J. Med. Chem. 50, 4939.
Product Information
FormOff-white solid
Hill FormulaC₁₃H₁₁F₃N₂O₂S
Chemical formulaC₁₃H₁₁F₃N₂O₂S
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22-36/38

Harmful if swallowed.
Irritating to eyes and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
324629 0

Documentation

Eg5 Inhibitor VI - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Eg5 Inhibitor VI - Calbiochem Certificates of Analysis

TitleLot Number
324629

References

Reference overview
Parrish, C.A., et al. 2007. J. Med. Chem. 50, 4939.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-October-2008 JSW
SynonymsN-(4ʹ-(Trifluoromethyl)-4-biphenyl)sulfamide, KSP Inhibitor VI
DescriptionA cell-permeable biphenylsulfamide compound that acts as a potent, reversible, and ATP-competitive inhibitor of Eg5/KSP ATPase activity (IC50 = 18 nM) with reactivity against both wild-type and the D130V mutant (Ki = 6.2 nM and 7 nM, respectively) in cell-free assays. Due to a higher ATP binding affinity of the WT enzyme, the inhibitor exhibits a much weaker antiproliferative activity against WT-expressing cells in cultures (IC50 = 5.4 and 403 nM, using HCT116 D130V and HCT116, respectively) and its in vivo antitumor efficacy has only been demonstrated in HCT116 D130V xenografed mice, but not mice with WT KSP-bearing Colo205.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₃H₁₁F₃N₂O₂S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (20 mg/ml) or Ethanol (15 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Harmful
ReferencesParrish, C.A., et al. 2007. J. Med. Chem. 50, 4939.