Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

324385 Doxycycline, Hyclate - CAS 24390-14-5 - Calbiochem

Doxycycline, Hyclate, CAS 24390-14-5, is a broad-spectrum antibiotic that acts as an inhibitor of MMP-8 (IC50 = 30 µM) relative to MMP-1 (IC50 = 300 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-6-Deoxy-5-hydroxytetracycline, Vibramycin, Hyclate

View Products on Sigmaaldrich.com
324385
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
24390-14-5C₂₂H₂₄N₂O₈ · HCl · 1/2(H₂O) · 1/2(C₂H₆O)
Description
OverviewA commonly-used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC50 = 30 µM) relative to MMP-1 (interstitial collagenase; IC50 = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC50 = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.
Catalogue Number324385
Brand Family Calbiochem®
Synonymsα-6-Deoxy-5-hydroxytetracycline, Vibramycin, Hyclate
References
ReferencesD’Agostino, P., et al. 1998. J. Infect. Dis. 177, 489.
Beekman, B., et al. 1997. Biochem. Biophys. Res. Commun. 237, 107.
Hanemaaijer, R., et al. 1997. J. Biol. Chem. 272, 31504.
Lauhio, A., et al. 1994. Clin. Exp. Immunol. Antimicrobiol. Agents Chemother. 36, 227.
Sorsa, T., et al. 1994. Ann. N.Y. Acad. Sci. 732, 112.
Suomalainen, K., et al. 1992. Antimicrobiol. Agents Chemother. 36, 227.
Product Information
CAS number24390-14-5
ATP CompetitiveN
FormYellow to yellow-green crystalline solid
Hill FormulaC₂₂H₂₄N₂O₈ · HCl · 1/2(H₂O) · 1/2(C₂H₆O)
Chemical formulaC₂₂H₂₄N₂O₈ · HCl · 1/2(H₂O) · 1/2(C₂H₆O)
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationDoxycycline, Hyclate, CAS 24390-14-5, is a broad-spectrum antibiotic that acts as an inhibitor of MMP-8 (IC50 = 30 µM) relative to MMP-1 (IC50 = 300 µM).
Biological Information
Primary TargetMMP-8
Primary Target IC<sub>50</sub>30 µM against MMP-8 (neutrophil collagenase); 25 µM inhibiting collagen synthesis by bovine articular chondrocytes cultured in alginate
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSQI8925000
Safety Information
R PhraseR: 20/21/22-63

Harmful by inhalation, in contact with skin and if swallowed.
Possible risk of harm to the unborn child.
S PhraseS: 22-36

Do not breathe dust.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollwing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 5 days at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
324385 0

Documentation

Doxycycline, Hyclate - CAS 24390-14-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Doxycycline, Hyclate - CAS 24390-14-5 - Calbiochem Certificates of Analysis

TitleLot Number
324385

References

Reference overview
D’Agostino, P., et al. 1998. J. Infect. Dis. 177, 489.
Beekman, B., et al. 1997. Biochem. Biophys. Res. Commun. 237, 107.
Hanemaaijer, R., et al. 1997. J. Biol. Chem. 272, 31504.
Lauhio, A., et al. 1994. Clin. Exp. Immunol. Antimicrobiol. Agents Chemother. 36, 227.
Sorsa, T., et al. 1994. Ann. N.Y. Acad. Sci. 732, 112.
Suomalainen, K., et al. 1992. Antimicrobiol. Agents Chemother. 36, 227.

Citations

Title
  • Mark Cannon, Ethel Cesarman and Chris Boshoff. (2006) The KSHV G-protein coupled receptor inhibits lytic gene transcription in primary effusion lymphoma cells via p21-mediated inhibition of Cdk1. Blood 107, 277-284.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision23-March-2018 JSW
    Synonymsα-6-Deoxy-5-hydroxytetracycline, Vibramycin, Hyclate
    DescriptionA commonly used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC50 = 30 µM) relative to MMP-1 (collagenase-1; IC50 = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC50 = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.
    FormYellow to yellow-green crystalline solid
    CAS number24390-14-5
    RTECSQI8925000
    Chemical formulaC₂₂H₂₄N₂O₈ · HCl · 1/2(H₂O) · 1/2(C₂H₆O)
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityH₂O (50 mg/ml)
    Storage +2°C to +8°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollwing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 5 days at 4°C.
    Toxicity Harmful & Carcinogenic / Teratogenic
    Merck USA index14, 3440
    ReferencesD’Agostino, P., et al. 1998. J. Infect. Dis. 177, 489.
    Beekman, B., et al. 1997. Biochem. Biophys. Res. Commun. 237, 107.
    Hanemaaijer, R., et al. 1997. J. Biol. Chem. 272, 31504.
    Lauhio, A., et al. 1994. Clin. Exp. Immunol. Antimicrobiol. Agents Chemother. 36, 227.
    Sorsa, T., et al. 1994. Ann. N.Y. Acad. Sci. 732, 112.
    Suomalainen, K., et al. 1992. Antimicrobiol. Agents Chemother. 36, 227.
    Citation
  • Mark Cannon, Ethel Cesarman and Chris Boshoff. (2006) The KSHV G-protein coupled receptor inhibits lytic gene transcription in primary effusion lymphoma cells via p21-mediated inhibition of Cdk1. Blood 107, 277-284.
    		•