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324380 Doxorubicin, Hydrochloride - CAS 25316-40-9 - Calbiochem

Doxorubicin HCl, CAS 25316-40-9, is an antitumor antibiotic that inhibits topoisomerase II (IC₅₀ = 100 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Adriamycin, 14-Hydroxydaunomycin, HCl

Primary Target: topoisomerase 2
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
25316-40-9C₂₇H₂₉NO₁₁ · HCl
Description
OverviewAntitumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC50 = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, thereby inhibiting nucleic acid synthesis. Induces apoptosis in rhabdomyosarcoma cell lines. Also available as a 10 mM solution in H2O (Cat. No. 504042).
Catalogue Number324380
Brand Family Calbiochem®
SynonymsAdriamycin, 14-Hydroxydaunomycin, HCl
References
ReferencesA'Hern, R.P., and Gore, M.E. 1995. J. Clin. Oncol. 13, 726.
Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
Noviello, E., et al. 1994. Mutat. Res. 311, 21.
Anderson, R.D., et al. 1993. Mutat. Res. 294, 215.
Hershko, C., et al. 1993. J. Lab. Clin. Med. 122, 245.
Jongmans, W., et al. 1993. Mutat. Res. 294, 207.
O'Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc. 270, 2089.
Theyer, G., et al. 1993. J. Urol. 150, 1544.
Tritton, T.R., and Yee, G. 1982. Science 217, 248.
Product Information
CAS number25316-40-9
ATP CompetitiveN
FormOrange to red powder
Hill FormulaC₂₇H₂₉NO₁₁ · HCl
Chemical formulaC₂₇H₂₉NO₁₁ · HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targettopoisomerase 2
Primary Target IC<sub>50</sub>100 nM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSQI9295900
Safety Information
R PhraseR: 45-46

May cause cancer.
May cause heritable genetic damage.
S PhraseS: 36/37-45-53-22-28

Wear suitable protective clothing and gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.
Do not breathe dust.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +15°C to +30°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C. Under acidic conditions doxorubicin is converted to a water-insoluble adriamycinone and a water soluble reducing sugar, daunosamine.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
324380 0

Documentation

Doxorubicin, Hydrochloride - CAS 25316-40-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Doxorubicin, Hydrochloride - CAS 25316-40-9 - Calbiochem Certificates of Analysis

TitleLot Number
324380

References

Reference overview
A'Hern, R.P., and Gore, M.E. 1995. J. Clin. Oncol. 13, 726.
Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
Noviello, E., et al. 1994. Mutat. Res. 311, 21.
Anderson, R.D., et al. 1993. Mutat. Res. 294, 215.
Hershko, C., et al. 1993. J. Lab. Clin. Med. 122, 245.
Jongmans, W., et al. 1993. Mutat. Res. 294, 207.
O'Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc. 270, 2089.
Theyer, G., et al. 1993. J. Urol. 150, 1544.
Tritton, T.R., and Yee, G. 1982. Science 217, 248.

Brochure

Title
Tools and Tips for Analyzing Apoptosis
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-May-2018 JSW
SynonymsAdriamycin, 14-Hydroxydaunomycin, HCl
DescriptionAn anti-tumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC50 = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, inhibiting nucleic acid synthesis. Cytotoxicity seems to be due to its ability to intercalate with DNA, interact with plasma membranes, and take part in oxidation-reduction reactions. Induces apoptosis in rhabdomyosarcoma cell lines.
FormOrange to red powder
CAS number25316-40-9
RTECSQI9295900
Chemical formulaC₂₇H₂₉NO₁₁ · HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (10 mg/ml)
Storage Protect from light
+15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C. Under acidic conditions doxorubicin is converted to a water-insoluble adriamycinone and a water soluble reducing sugar, daunosamine.
Toxicity Carcinogenic / Teratogenic
Merck USA index14, 3439
ReferencesA'Hern, R.P., and Gore, M.E. 1995. J. Clin. Oncol. 13, 726.
Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
Noviello, E., et al. 1994. Mutat. Res. 311, 21.
Anderson, R.D., et al. 1993. Mutat. Res. 294, 215.
Hershko, C., et al. 1993. J. Lab. Clin. Med. 122, 245.
Jongmans, W., et al. 1993. Mutat. Res. 294, 207.
O'Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc. 270, 2089.
Theyer, G., et al. 1993. J. Urol. 150, 1544.
Tritton, T.R., and Yee, G. 1982. Science 217, 248.