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251400 D609, Potassium Salt - CAS 83373-60-8 - Calbiochem

Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki = 5-10 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Tricyclodecan-9-yl-xanthogenate, K

Primary Target: pc-specificphopholipase c
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
83373-60-8C₁₁H₁₅OS₂ · K

Products

Catalogue NumberPackaging Qty/Pack
251400-5MG Plastic ampoule 5 mg
Description
OverviewSelective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki = 5-10 µM). Does not inhibit phosphatidylinositol-specific phospholipase C, phospholipase A, or phospholipase D. Also reported to inhibit LPS-stimulated ERK activation via its inhibitory effect on PLC. Inhibits angiogenesis by preventing the synthesis of basement membrane.
Catalogue Number251400
Brand Family Calbiochem®
SynonymsTricyclodecan-9-yl-xanthogenate, K
References
ReferencesMonick, M.M., et al. 1999. J. Immunol. 162, 3005.
Lozanski, G., et al. 1997. Biochem. J. 328, 271.
Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
Doppler, C., et al. 1992. AIDS Res. Human Retroviruses 8, 245.
Schutze, S., et al. 1992. Cell 71, 765.
Sauer, G., et al. 1990. Cancer Lett. 53, 97.
Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun. 162, 198.
Amtmann, E., et al. 1987. Biochem. Pharmacol. 36, 1545.
Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 3263.
Product Information
CAS number83373-60-8
ATP CompetitiveN
FormOff-white powder
Hill FormulaC₁₁H₁₅OS₂ · K
Chemical formulaC₁₁H₁₅OS₂ · K
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetpc-specificphopholipase c
Primary Target K<sub>i</sub>5-10 µM against phosphatidylcholine (PC)-specific phospholipase C
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsMaterial is very labile once in solution (1.5 day half-life in tissue culture medium).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
251400-5MG 04055977199208

Documentation

D609, Potassium Salt - CAS 83373-60-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

D609, Potassium Salt - CAS 83373-60-8 - Calbiochem Certificates of Analysis

TitleLot Number
251400

References

Reference overview
Monick, M.M., et al. 1999. J. Immunol. 162, 3005.
Lozanski, G., et al. 1997. Biochem. J. 328, 271.
Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
Doppler, C., et al. 1992. AIDS Res. Human Retroviruses 8, 245.
Schutze, S., et al. 1992. Cell 71, 765.
Sauer, G., et al. 1990. Cancer Lett. 53, 97.
Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun. 162, 198.
Amtmann, E., et al. 1987. Biochem. Pharmacol. 36, 1545.
Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 3263.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-September-2010 JSW
SynonymsTricyclodecan-9-yl-xanthogenate, K
DescriptionSelective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) (Bacillus cereus, Ki = 5-10 µM). Does not inhibit (up to 50 µM) phosphatidylinositol-specific phospholipase C, phospholipase A2, and phospholipase D. Inhibitor of the sphingomyelinase activity. Also inhibits angiogenesis by preventing the synthesis of basement membrane (BM).
FormOff-white powder
CAS number83373-60-8
Chemical formulaC₁₁H₁₅OS₂ · K
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (25 mg/ml) and DMSO (25 mg/ml). Note: tissue culture media should be at neutral pH, since product is active only at or slightly below pH 7.0. The compound is inactive at pH 7.4 and above, and it is hydrolyzed below pH 6.0. HEPES buffer should not be used as it renders D609 toxic.
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsMaterial is very labile once in solution (1.5 day half-life in tissue culture medium).
Toxicity Standard Handling
ReferencesMonick, M.M., et al. 1999. J. Immunol. 162, 3005.
Lozanski, G., et al. 1997. Biochem. J. 328, 271.
Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147.
Doppler, C., et al. 1992. AIDS Res. Human Retroviruses 8, 245.
Schutze, S., et al. 1992. Cell 71, 765.
Sauer, G., et al. 1990. Cancer Lett. 53, 97.
Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun. 162, 198.
Amtmann, E., et al. 1987. Biochem. Pharmacol. 36, 1545.
Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 3263.