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230950 Ciglitazone - CAS 74772-77-3 - Calbiochem

A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective PPARγ agonist (EC₅₀ = 3 µM).

Ciglitazone - CAS 74772-77-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione, PPAR Agonist II, PPARγ Agonist I

Primary Target: Selective PPARγ agonist
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
74772-77-3C₁₈H₂₃NO₃S

Products

Catalogue NumberPackaging Qty/Pack
230950-5MG Plastic ampoule 5 mg
Description
OverviewA potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective PPARγ agonist (EC50 = 3 µM).
Catalogue Number230950
Brand Family Calbiochem®
Synonyms(±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione, PPAR Agonist II, PPARγ Agonist I
References
ReferencesJha, R.J. 1999. Clin. Exp. Hypertens. 21, 157.
Xin, X., et al. 1999. J. Biol. Chem. 274, 9116.
Lohrke, B., et al. 1998. J. Endocrinol. 159, 429.
Willson, T.M., et al. 1996. J. Med. Chem. 39, 665.
Cantello, B.C., et al. 1994. J. Med. Chem. 37, 3977.
Product Information
CAS number74772-77-3
ATP CompetitiveN
FormWhite to tan solid
Hill FormulaC₁₈H₂₃NO₃S
Chemical formulaC₁₈H₂₃NO₃S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetSelective PPARγ agonist
Primary Target IC<sub>50</sub>EC50 = 3 µM as PPARγ agonist
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSXJ5813700
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsStock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
230950-5MG 04055977218312

Documentation

Ciglitazone - CAS 74772-77-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Ciglitazone - CAS 74772-77-3 - Calbiochem Certificates of Analysis

TitleLot Number
230950

References

Reference overview
Jha, R.J. 1999. Clin. Exp. Hypertens. 21, 157.
Xin, X., et al. 1999. J. Biol. Chem. 274, 9116.
Lohrke, B., et al. 1998. J. Endocrinol. 159, 429.
Willson, T.M., et al. 1996. J. Med. Chem. 39, 665.
Cantello, B.C., et al. 1994. J. Med. Chem. 37, 3977.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-January-2020 JSW
Synonyms(±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione, PPAR Agonist II, PPARγ Agonist I
DescriptionA potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 3 µM).
FormWhite to tan solid
CAS number74772-77-3
RTECSXJ5813700
Chemical formulaC₁₈H₂₃NO₃S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (≥ 25 mg/ml) or Ethanol (≥25 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsStock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesJha, R.J. 1999. Clin. Exp. Hypertens. 21, 157.
Xin, X., et al. 1999. J. Biol. Chem. 274, 9116.
Lohrke, B., et al. 1998. J. Endocrinol. 159, 429.
Willson, T.M., et al. 1996. J. Med. Chem. 39, 665.
Cantello, B.C., et al. 1994. J. Med. Chem. 37, 3977.