Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

342000 Caspase Inhibitor, Negative Control - CAS 105637-38-5 - Calbiochem

The Caspase Inhibitor, Negative Control, also referenced under CAS 105637-38-5, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-FA-FMK, Cathepsin B, Inhibitor I

Primary Target: Cathepsin-B
View Products on Sigmaaldrich.com
342000
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
105637-38-5C₂₁H₂₃FN₂O₄
Description
OverviewA cell-permeable, irreversible cathepsin B inhibitor. Blocks LPS-induced production of IL-1α and IL-1β. Suitable as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position.
Catalogue Number342000
Brand Family Calbiochem®
SynonymsZ-FA-FMK, Cathepsin B, Inhibitor I
References
ReferencesSchotte, P., et al. 2001. J. Biol. Chem. 276, 21153.
Guo, H., et al. 1998. Exp. Cell Res. 245, 57.
Rosenthal, P.J., et al. 1993. J. Clin. Invest. 91, 1057.
Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44, 1201.
Rauber, P., et al. 1986. Biochem. J. 239, 633.
Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
Rasnick, D. 1985. Anal. Biochem. 149, 461.
Product Information
CAS number105637-38-5
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₁H₂₃FN₂O₄
Chemical formulaC₂₁H₂₃FN₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCathepsin-B
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Phe-Ala-FMK
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
342000 0

Documentation

Caspase Inhibitor, Negative Control - CAS 105637-38-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase Inhibitor, Negative Control - CAS 105637-38-5 - Calbiochem Certificates of Analysis

TitleLot Number
342000

References

Reference overview
Schotte, P., et al. 2001. J. Biol. Chem. 276, 21153.
Guo, H., et al. 1998. Exp. Cell Res. 245, 57.
Rosenthal, P.J., et al. 1993. J. Clin. Invest. 91, 1057.
Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44, 1201.
Rauber, P., et al. 1986. Biochem. J. 239, 633.
Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
Rasnick, D. 1985. Anal. Biochem. 149, 461.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Cathepsins and Related Products Technical Bulletin

Citations

Title
  • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision07-April-2008 RFH
    SynonymsZ-FA-FMK, Cathepsin B, Inhibitor I
    DescriptionA cell-permeable, irreversible cathepsin B inhibitor that may be potentially useful in treating arthritis. Suitable as a negative control for caspase-1 inhibition studies.
    FormOff-white solid
    CAS number105637-38-5
    Chemical formulaC₂₁H₂₃FN₂O₄
    Peptide SequenceZ-Phe-Ala-FMK
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (10 mg/ml)
    Storage Protect from moisture
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesSchotte, P., et al. 2001. J. Biol. Chem. 276, 21153.
    Guo, H., et al. 1998. Exp. Cell Res. 245, 57.
    Rosenthal, P.J., et al. 1993. J. Clin. Invest. 91, 1057.
    Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44, 1201.
    Rauber, P., et al. 1986. Biochem. J. 239, 633.
    Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
    Rasnick, D. 1985. Anal. Biochem. 149, 461.
    Citation
  • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
    		•