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218830 Caspase Inhibitor II, Cell-Permeable - Calbiochem

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218830
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₈₈H₁₅₁N₁₉O₂₂
Description
Overview

This product has been discontinued.



A cell-permeable, reversible pan-caspase inhibitor produced by attaching the N-terminal sequence (amino acids 1-16) of the Kaposi fibroblast growth factor signaling peptide, which imparts cell-permeability to VAD peptide.

Catalogue Number218830
Brand Family Calbiochem®
Synonymscpm-VAD-CHO; sequence
References
ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Lin, Y-Z., et al. 1996. J. Biol. Chem. 271, 5305.
Lin, Y-Z., et al. 1995. J. Biol. Chem. 270, 14255.
Product Information
FormWhite solid
Hill FormulaC₈₈H₁₅₁N₁₉O₂₂
Chemical formulaC₈₈H₁₅₁N₁₉O₂₂
Hygroscopic Hygroscopic
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Targetcaspase-1-like proteases
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Ala-Asp-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
218830 0

Documentation

Caspase Inhibitor II, Cell-Permeable - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase Inhibitor II, Cell-Permeable - Calbiochem Certificates of Analysis

TitleLot Number
218830

References

Reference overview
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Lin, Y-Z., et al. 1996. J. Biol. Chem. 271, 5305.
Lin, Y-Z., et al. 1995. J. Biol. Chem. 270, 14255.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure

Citations

Title
Xu, J., et al. 2009. The Journal of Neuroscience, 29 9330.
Carmagnat M., et al. 2006. Oncogene 25, 1914.
IM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-June-2008 RFH
Synonymscpm-VAD-CHO; sequence
DescriptionA cell-permeable, reversible inhibitor of caspase-1-like proteases. Constructed by attaching the N-terminal sequence (amino acids 1-16) of the Kaposi fibroblast growth factor signaling peptide to Caspase Inhibitor II (Cat. No. 218735), which imparts cell-permeability to this peptide.
FormWhite solid
Chemical formulaC₈₈H₁₅₁N₁₉O₂₂
Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Ala-Asp-CHO
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Lin, Y-Z., et al. 1996. J. Biol. Chem. 271, 5305.
Lin, Y-Z., et al. 1995. J. Biol. Chem. 270, 14255.
CitationXu, J., et al. 2009. The Journal of Neuroscience, 29 9330.
Carmagnat M., et al. 2006. Oncogene 25, 1914.
IM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.