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235420 Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem

The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CPP32/Apopain Inhibitor, Ac-DEVD-CHO

Primary Target: Capase-3, capase-6, capase-7, capase-8, capase-10
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235420
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
169332-60-9C₂₀H₃₀N₄O₁₁

Products

Catalogue NumberPackaging Qty/Pack
235420-1MG Glass bottle 1 mg
235420-5MG Plastic ampoule 5 mg
Description
OverviewA very potent, specific, and reversible inhibitor of caspase-3 (IC50 = 200 pM), caspase-6, caspase-7, caspase-8, and caspase-10.
Catalogue Number235420
Brand Family Calbiochem®
SynonymsCPP32/Apopain Inhibitor, Ac-DEVD-CHO
References
ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature 376, 37.
Product Information
CAS number169332-60-9
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₀H₃₀N₄O₁₁
Chemical formulaC₂₀H₃₀N₄O₁₁
ReversibleY
Sold on the basis of peptide contentY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCapase-3, capase-6, capase-7, capase-8, capase-10
Primary Target IC<sub>50</sub>200 pM against caspase-3
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Peptide ContentY
Peptide SequenceAc-Asp-Glu-Val-Asp-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
235420-1MG 07790788060220
235420-5MG 04055977199697

Documentation

Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem Certificates of Analysis

TitleLot Number
235420

References

Reference overview
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature 376, 37.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure

Citations

Title
  • Qian Zhang and Bibhash C. Paria. (2006) Importance of Uterine Cell Death, Renewal and Their Hormonal Regulation in Hamsters That Show Progesterone-dependent Implantation. Endocrinology 147, 2215-2227.
  • So-Young Park and Adriana Ferreira. (2005) The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which Tau mediates β-amyloid-induced neurodegeneration. Journal of Neuroscience 25, 5365-5375.
  • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision31-March-2011 RFH
    SynonymsCPP32/Apopain Inhibitor, Ac-DEVD-CHO
    DescriptionA specific and reversible inhibitor of CPP32/Apopain/Yama (IC50 = 0.2 nM). A member of the ICE/CED-3 family of cysteine proteases, which are important in apoptosis.
    FormWhite solid
    CAS number169332-60-9
    Chemical formulaC₂₀H₃₀N₄O₁₁
    Peptide SequenceAc-Asp-Glu-Val-Asp-CHO
    Structure formulaStructure formula
    Purity≥90% by HPLC
    SolubilityDMSO (5 mg/ml) or H₂O
    Storage -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
    Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
    Nicholson, D.W. 1996. Nature Biotech. 14, 297.
    Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
    Nicholson, D.W., et al. 1995. Nature 376, 37.
    Citation
  • Qian Zhang and Bibhash C. Paria. (2006) Importance of Uterine Cell Death, Renewal and Their Hormonal Regulation in Hamsters That Show Progesterone-dependent Implantation. Endocrinology 147, 2215-2227.
  • So-Young Park and Adriana Ferreira. (2005) The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which Tau mediates β-amyloid-induced neurodegeneration. Journal of Neuroscience 25, 5365-5375.
  • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.
    		•