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505766 Casein Kinase II Inhibitor XII, TBBz - CAS 577779-57-8 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4,5,6,7-Tetrabromobenzimidazole, CYP24A1 inhibitor, TBBz, CK2 Inhibitor, TBBz

Primary Target: CK2
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
577779-57-8C₇H₂Br₄N₂
Description
OverviewA cell-permeable halogenated benzimidazole compound that acts as a selective and ATP competitive inhibitor of casein kinase II (CK2, Ki = 70 nM for the active hetero-tetrameric form). However, its effect on free CK2a and CK2a′ subunits is significantly reduced (Ki = 510 and 400 nM, respectively). Reported to reduce viability and proliferation in HeLa, Jurkat, and HL-60 cells (at ˜25 µM). Also shown to disrupt the promoter activity of CYP24A1 and down-regulates its endogenous and 1, 25-Vitamin D3 (1,25-D3)-induced expression in PC3 cells. Synergistically enhances the anti-tumor effect of 1, 25-D3 in a PC3 xenograft murine model.
Catalogue Number505766
Brand Family Calbiochem®
Synonyms4,5,6,7-Tetrabromobenzimidazole, CYP24A1 inhibitor, TBBz, CK2 Inhibitor, TBBz
References
ReferencesSzyszka, R. et al. 1995. Biochem. Biophys. Res. Comm. 208, 418.
Zien, P. et al. 2003. Biochem. Biophys. Res. Comm. 306, 129.
Zien, P. et al. 2003. Biochem. Biophys. Res. Comm. 312, 623.
Zien, P. et al. 2005. Biochim. Biophy. Acta 1754, 271.
Luo, W. et al. 2013. Cancer Res. 73, 2289.
Product Information
CAS number577779-57-8
FormOff-white powder
Hill FormulaC₇H₂Br₄N₂
Chemical formulaC₇H₂Br₄N₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCK2
Primary Target K<sub>i</sub>70 nM
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
505766 0

Documentation

Casein Kinase II Inhibitor XII, TBBz - CAS 577779-57-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Szyszka, R. et al. 1995. Biochem. Biophys. Res. Comm. 208, 418.
Zien, P. et al. 2003. Biochem. Biophys. Res. Comm. 306, 129.
Zien, P. et al. 2003. Biochem. Biophys. Res. Comm. 312, 623.
Zien, P. et al. 2005. Biochim. Biophy. Acta 1754, 271.
Luo, W. et al. 2013. Cancer Res. 73, 2289.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-October-2013 JSW
Synonyms4,5,6,7-Tetrabromobenzimidazole, CYP24A1 inhibitor, TBBz, CK2 Inhibitor, TBBz
DescriptionA cell-permeable halogenated benzimidazole compound that acts as a selective and ATP competitive inhibitor of casein kinase II (CK2, Ki = 70 nM for the active hetero-tetrameric form). However, its effect on free CK2a and CK2a′ subunits is significantly reduced (Ki = 510 and 400 nM, respectively). Reported to reduce viability and proliferation in HeLa, Jurkat, and HL-60 cells (at ˜25 µM). Also shown to disrupt the promoter activity of CYP24A1 and down-regulates its endogenous and 1, 25-Vitamin D3 (1,25-D3)-induced expression in PC3 cells. Synergistically enhances the anti-tumor effect of 1, 25-D3 in a PC3 xenograft murine model.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number577779-57-8
Chemical formulaC₇H₂Br₄N₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSzyszka, R. et al. 1995. Biochem. Biophys. Res. Comm. 208, 418.
Zien, P. et al. 2003. Biochem. Biophys. Res. Comm. 306, 129.
Zien, P. et al. 2003. Biochem. Biophys. Res. Comm. 312, 623.
Zien, P. et al. 2005. Biochim. Biophy. Acta 1754, 271.
Luo, W. et al. 2013. Cancer Res. 73, 2289.