Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

504041 CaCC Blocker IV, Benzbromarone - CAS 3562-84-3 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (3,5-dibromo-4-hydroxyphenyl)(2-ethylbenzofuran-3-yl)methanone, ANO Blocker IV, Anoctamin Blocker IV, BBR, CaCC Blocker IV, Calcium-Activated Chloride Channel Blocker IV, TMEM16 Blocker IV

Primary Target: TMEM16A-CaCC
View Products on Sigmaaldrich.com
504041
Purchase on Sigma-Aldrich

Overview

Key Spec Table

CAS #Empirical Formula
3562-84-3C₁₇H₁₂Br₂O₃

Products

Catalogue NumberPackaging Qty/Pack
5.04041.0001 Glass bottle 100 mg
Add To Favorites
Description
OverviewA cell-permeable uricosuric agent that, in addition to its known efficacy in gout treatment, acts as a reversible CaCC blocker and is reported to be more potent than NFA (Cat. No. 481987) and NPPB (Cat. No. 484100) in suppressing 500 nM Ionomycin- (Cat. Nos. 407950, 407952, and 407953) induced I- influx in TMEM16A-expressing HEK293 cells (IC50 = 9.97, 140, and 150 µM, respectively) as well as in blocking voltage-gated Cl- current in TMEM16B-expressing HEK293 cells, while exhibiting much reduced potency against ENaC (α, β, and γ) or CFTR. Shown to significantly reduce mucin secretion from NHBE (normal human bronchial epithelial) and suppress human ASM (airway smooth muscle) contraction upon muscarinic receptor stimulation.
Catalogue Number504041
Brand Family Calbiochem®
Synonyms(3,5-dibromo-4-hydroxyphenyl)(2-ethylbenzofuran-3-yl)methanone, ANO Blocker IV, Anoctamin Blocker IV, BBR, CaCC Blocker IV, Calcium-Activated Chloride Channel Blocker IV, TMEM16 Blocker IV
References
ReferencesKobayashi, K., et al. 2012. Drug Metab. Pharmacokinet. In press.
Zhang, C.H., et al. 2013. Am. J. Respir. Crit. Care Med. 187, 374.
Huang, F., et al. 2012. Proc. Natl. Acad. Sci. USA. 109, 16354.
Fujimori, S., et al. 2011. Nucleosides Nucleotides Nucleic Acids 30, 1035.
Perez-Ruiz, F., et al. 1998. Ann. Rheum. Dis. 57, 545.
Product Information
CAS number3562-84-3
FormWhite powder
Hill FormulaC₁₇H₁₂Br₂O₃
Chemical formulaC₁₇H₁₂Br₂O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetTMEM16A-CaCC
Purity≥97% by HPLC
Safety Information
R PhraseR: 25

Toxic if swallowed.
S PhraseS: 45

In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
5.04041.0001 04055977264234