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236007 COX-1 Inhibitor IV, TFAP - CAS 1011244-68-0 - Calbiochem

The COX-1 Inhibitor IV, TFAP, also referenced under CAS 1011244-68-0, controls the biological activity of COX-1. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1011244-68-0C₁₃H₁₀F₃N₃O
Description
OverviewA cell-permeable pyridinyl-benzamide compound that acts as a COX-1-selective inhibitor (IC50 = 0.80 and 210 µM against ovine COX-1 and COX-2, respectively) by targeting the enzyme's active site and displays analgesic properties in mice and rats in vivo (30 mg/kg, p.o.) without long-term cytotoxic effects (300 mg/kg in mice, daily, p.o. for 14 days). Unlike COX-2-inhibiting analgesics such as aspirin, TFAP is shown not to cause gastric damage in rats in vivo (300 mg/kg, p.o.).
Catalogue Number236007
Brand Family Calbiochem®
SynonymsN-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide
References
ReferencesKakuta, H., et al. 2008. J. Med. Chem. 51, 2400.
Product Information
CAS number1011244-68-0
FormOff-white solid
Hill FormulaC₁₃H₁₀F₃N₃O
Chemical formulaC₁₃H₁₀F₃N₃O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25

Do not breathe dust.
Avoid contact with skin and eyes.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
236007 0

Documentation

COX-1 Inhibitor IV, TFAP - CAS 1011244-68-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

COX-1 Inhibitor IV, TFAP - CAS 1011244-68-0 - Calbiochem Certificates of Analysis

TitleLot Number
236007

References

Reference overview
Kakuta, H., et al. 2008. J. Med. Chem. 51, 2400.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-April-2011 RFH
SynonymsN-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide
DescriptionA cell-permeable pyridinyl-benzamide compound that acts as a COX-1-selective inhibitor (IC50 = 0.80 and 210 µM against ovine COX-1 and COX-2, respectively) by targeting the enzyme's active site and displays analgesic properties in mice and rats in vivo (30 mg/kg, p.o.) without long-term cytotoxic effects (300 mg/kg in mice, daily p.o. for 14 days). Unlike COX-2-inhibiting analgesics such as aspirin, TFAP is shown not to cause gastric damage in rats in vivo (300 mg/kg, p.o.).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1011244-68-0
Chemical formulaC₁₃H₁₀F₃N₃O
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKakuta, H., et al. 2008. J. Med. Chem. 51, 2400.