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231180 CITCO

CITCO MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime

231180
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
338404-52-7C₁₉H₁₂Cl₃N₃OS
Description
Overview

This product has been discontinued.





A cell-permeable imidazothiazole compound that acts as a potent and selective agonist for the human orphan nuclear constitutive androstane receptor (CAR). Displays ~ 100-fold greater selectivity for CAR over xenobiotic pregnane X receptor (PXR) in transient transfection assays (EC50 = 25 nM vs. 3 µM) and shows no detectable activity on 15 other nuclear receptors tested even at concentrations as high as 10 µM.
Catalogue Number231180
Brand Family Calbiochem®
Synonyms6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime
References
ReferencesMaglich, J.M., et al. 2003. J. Biol. Chem. 278, 17277.
Wang, H., and Negishi, M. 2003. Curr. Drug Metab. 4, 515.
Product Information
CAS number338404-52-7
FormPale orange solid
Hill FormulaC₁₉H₁₂Cl₃N₃OS
Chemical formulaC₁₉H₁₂Cl₃N₃OS
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥98% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
231180 0

Documentation

CITCO Certificates of Analysis

TitleLot Number
231180

References

Reference overview
Maglich, J.M., et al. 2003. J. Biol. Chem. 278, 17277.
Wang, H., and Negishi, M. 2003. Curr. Drug Metab. 4, 515.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2008 RFH
Synonyms6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime
DescriptionA cell-permeable imidazothiazole compound that acts as a potent and selective agonist for the human orphan nuclear constitutive androstane receptor (CAR). Displays ~100-fold greater selectivity for CAR over xenobiotic pregnane X receptor (PXR) in transient transfection assays (EC50 = 25 nM vs. 3 µM, respectively). Does not exhibit detectable activity on 15 additional nuclear receptors tested, even at concentrations as high as 10 µM.
FormPale orange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number338404-52-7
Chemical formulaC₁₉H₁₂Cl₃N₃OS
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesMaglich, J.M., et al. 2003. J. Biol. Chem. 278, 17277.
Wang, H., and Negishi, M. 2003. Curr. Drug Metab. 4, 515.